{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:04:46Z","timestamp":1756897486217,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the prevalence and predictive factors of xerostomia during induction chemotherapy (IC) in patients with nasopharyngeal carcinoma (NPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively enrolled NPC patients who received IC between October 2020 and October 2021. The Visual Analogue Scale (VAS) and Xerostomia Inventory (XI) were used to evaluate the condition of xerostomia. The volume of the submandibular gland (SMG) was also calculated before and after IC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010two patients were enrolled in this study. Of these patients, 32.7% (<jats:italic>n<\/jats:italic>\u2009=\u200917) experienced xerostomia before IC. There were 32 (61.5%) patients suffered from xerostomia after IC, including 21 (40.4%) patients with newly diagnosed xerostomia after IC and 11 (21.1%) patients complained their xerostomia aggravated in those with xerostomia before IC. The median XI scores increased from 11 (standard deviation [SD], 2.930) to 18 (SD 3.995), 16 (SD 3.605), and 17 (SD 4.331) after the first, second, and third cycles of IC, respectively. The median score of VAS also increased from 0 to 4 during the following three cycles of IC. In those with IC\u2010related xerostomia, the SMG volume after IC was significantly decreased compared with those without IC\u2010related xerostomia (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). The reduction of the SMG volume after IC was the independent risk factor for xerostomia (<jats:italic>P<\/jats:italic>\u2009=\u20090.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Approximately two\u2010thirds of NPC patients suffered from IC\u2010related xerostomia and patients with a reduction of SMG volume after IC had a higher risk of xerostomia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27529","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T11:10:41Z","timestamp":1695726641000},"page":"3024-3032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Xerostomia: An easily ignored symptom induced by induction chemotherapy in patients with nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"45","author":[{"given":"Ping","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Xiamen Cancer Center, Xiamen Key Laboratory of Radiation Oncology The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Xiamen Cancer Center, Xiamen Key Laboratory of Radiation Oncology The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Feng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Xiamen Cancer Center, Xiamen Key Laboratory of Radiation Oncology The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Yue","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Xiamen University, School of Medicine Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-2614","authenticated-orcid":false,"given":"San\u2010Gang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Xiamen Cancer Center, Xiamen Key Laboratory of Radiation Oncology The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30198"},{"key":"e_1_2_11_4_1","unstructured":"National Comprehensive Cancer Network.NCCN Clinical Practice Guidelines in Oncology: Head and Neck Cancer. 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