{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:44:05Z","timestamp":1779335045583,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Head and neck (H&amp;N) sarcomas in children can poise numerous challenges to the surgical oncologist and require multidisciplinary input and meticulous surgical planning. The application of computer\u2010assisted design\/computer\u2010assisted manufacturing (CAD\/CAM) has been extensively examined in H&amp;N reconstruction in adults, but its utility in ablative oncologic surgery in children warrants further examination. We present preliminary results utilizing CAD\/CAM techniques to assist in planning tumor resections and the application of intra\u2010operative radiation in children with skull\u2010base sarcomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort review of all pediatric patients who presented to a tertiary care cancer center for surgical resection of a skull\u2010base malignancy was performed between 1980 and 2021. All children under 18\u2009years of age with diagnosis of a skull\u2010base sarcoma as confirmed with imaging and pathology were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 21 children were identified but only four children with skull\u2010base sarcomas had diagnostic imaging available in whom computer\u2010assisted volumetric analyses were generated. In these cases, CAD\/CAM was used to plan surgical approaches and intraoperative radiotherapy, significantly aiding in treatment for these complicated pediatric cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CAD\/CAM planning for oncologic resection has huge potential. Here we have shown its utility in pre\u2010operative surgical planning and for administration of intraoperative radiation therapy. Future studies are needed to examine its value in facilitating intraoperative surgical management and patient outcomes, as well as cost effectiveness.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27534","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T10:36:19Z","timestamp":1696934179000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>CAD<\/scp>\/<scp>CAM<\/scp>\u2010assisted ablative surgery and intraoperative brachytherapy for pediatric skull\u2010base sarcomas"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3001-1109","authenticated-orcid":false,"given":"Joseph","family":"Lopez","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Head and Neck Surgery Memorial Sloan Kettering Cancer Center New York  New York New York USA"},{"name":"Department of Surgery, Division of Pediatric Head &amp; Neck Surgery AdventHealth for Children  Orlando Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0323-6716","authenticated-orcid":false,"given":"Tejas","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Head and Neck Surgery Memorial Sloan Kettering Cancer Center New York  New York New York USA"},{"name":"Weill Cornell Medical College New York  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilda","family":"Stambuk","sequence":"additional","affiliation":[{"name":"Department of Radiology Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Schreyer","sequence":"additional","affiliation":[{"name":"Department of Radiology Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robbie","family":"Woods","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Head and Neck Surgery Memorial Sloan Kettering Cancer Center New York  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Scholfield","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Head and Neck Surgery Memorial Sloan Kettering Cancer Center New York  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Head and Neck Surgery Memorial Sloan Kettering Cancer Center New York  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6104-7967","authenticated-orcid":false,"given":"Marc A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Head and Neck Surgery Memorial Sloan Kettering Cancer Center New York  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jatin","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Head and Neck Surgery Memorial Sloan Kettering Cancer Center New York  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7636-5426","authenticated-orcid":false,"given":"Ian","family":"Ganly","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Head and Neck Surgery Memorial Sloan Kettering Cancer Center New York  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2018.05.010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/2177-6709.21.1.089-100.oar"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph182111349"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2012.03.015"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23540"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24684"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp.2018.06.01"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2013.03.007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2014.920988"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21118"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1538\u20104721(03)00135\u20101"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.5114\/jcb.2010.14407"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.27534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T11:30:41Z","timestamp":1699615841000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.27534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,10]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/hed.27534"],"URL":"https:\/\/doi.org\/10.1002\/hed.27534","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,10]]},"assertion":[{"value":"2023-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}