{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:12:51Z","timestamp":1780431171661,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T00:00:00Z","timestamp":1697932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Salvage total laryngectomy (STL) is a preferred treatment for patients with residual, recurrent, and second primary squamous cell carcinoma of the larynx\/hypopharynx after (chemo)radiation. To individually estimate postoperative oncological outcomes, we designed and validated prognostic nomograms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used a dataset of 290 patients who underwent STL. Nomograms predicting 2\u2010 and 5\u2010year OS, DFS, and DSS were developed, using variables which are identified pre\u2010 or postoperatively. The nomograms were externally validated on a dataset of 109 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The nomograms based on postoperative variables performed better than those based on preoperative variables (OS: C\u2009=\u20090.68 vs. 0.64; DFS: C\u2009=\u20090.70 vs. 0.64; DSS: C\u2009=\u20090.74 vs. 0.64). The nomogram predicting DSS based on postoperative variables performed best.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presented prognostic nomograms for predicting oncological outcomes in patients who undergo STL are tools which allow for a reliable prognostic assessment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27556","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T05:15:17Z","timestamp":1698038117000},"page":"46-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Salvage total laryngectomy for squamous cell carcinoma of the larynx and hypopharynx: Validated prognostic nomograms predicting oncological outcomes"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1761-1222","authenticated-orcid":false,"given":"Jeroen","family":"Meulemans","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery University Hospital Leuven  Leuven Belgium"},{"name":"Department of Oncology Section Head and Neck Oncology, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Van Boven","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery University Hospital Leuven  Leuven Belgium"},{"name":"Department of Oncology Section Head and Neck Oncology, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8293-2885","authenticated-orcid":false,"given":"Jens","family":"Debacker","sequence":"additional","affiliation":[{"name":"Department of Head and Skin Ghent University  Ghent Belgium"},{"name":"Department of Nuclear Medicine UZ Brussel  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annouschka","family":"Laenen","sequence":"additional","affiliation":[{"name":"Interuniversity Institute for Biostatistics and Statistical Bioinformatics  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Delaere","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery University Hospital Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Van Lierde","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery University Hospital Leuven  Leuven Belgium"},{"name":"Department of Oncology Section Head and Neck Oncology, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"Huvenne","sequence":"additional","affiliation":[{"name":"Department of Head and Skin Ghent University  Ghent Belgium"},{"name":"Department of Head and Neck Surgery Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1341-829X","authenticated-orcid":false,"given":"Vincent","family":"Vander Poorten","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery University Hospital Leuven  Leuven Belgium"},{"name":"Department of Oncology Section Head and Neck Oncology, KU Leuven  Leuven 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