{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:10:06Z","timestamp":1747149006025,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T00:00:00Z","timestamp":1698451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Late laryngopharyngeal cancers after transoral surgery include not only local recurrences but also metachronous multiple cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared clinical information, surgical outcomes, and late laryngopharyngeal cancers in patients who underwent transoral nonrobotic surgery for laryngopharyngeal squamous cell carcinoma without lymph node metastases between 2015 and 2021 in a multicenter retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred and fifty\u2010seven patients were included. Positive surgical margins were found in 121 patients (26.5%). Twenty\u2010two patients (4.8%) received additional treatment. Positive horizontal margins of invasive carcinoma (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) and positive horizontal margins of carcinoma in situ only (<jats:italic>p<\/jats:italic>\u2009=\u20090.032) were independent risk factors for local recurrence, and prior radiotherapy (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) for metachronous multiple cancers. Local control was significantly worse without additional treatment (<jats:italic>p<\/jats:italic>\u2009=\u20090.049), but there was no significant difference in survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with positive margins had an increased frequency of local recurrence, but salvage therapy was effective.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27564","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T08:28:41Z","timestamp":1698481721000},"page":"118-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Local recurrence and metachronous multiple cancers after transoral nonrobotic surgery for pharyngeal and laryngeal squamous cell carcinoma: A retrospective multicenter study"],"prefix":"10.1002","volume":"46","author":[{"given":"Koji","family":"Ushiro","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery National Hospital Organization Kyoto Medical Center  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Japanese Red Cross Osaka Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3583-0165","authenticated-orcid":false,"given":"Yo","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Asato","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery National Hospital Organization Kyoto Medical Center  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Tsujimura","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Japanese Red Cross Wakayama Medical Center  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryusuke","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Occupational and Environmental Health  Kitakyushu Japan"},{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Fujita Health University  Toyoake Japan"},{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Tenri Hospital  Tenri Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Kumabe","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Hyogo Prefectural Amagasaki General Medical Center  Amagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Hyogo Prefectural Amagasaki General Medical Center  Amagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisanobu","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Kurashiki Central Hospital  Kurashiki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Iki","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Kurashiki Central Hospital  Kurashiki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiharu","family":"Kitani","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Shizuoka General Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Kurata","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Shizuoka General Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Kyoto University Graduate School of Medicine  Kyoto Japan"},{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Tenri Hospital  Tenri Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuniaki","family":"Takata","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Tenri Hospital  Tenri Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinpei","family":"Kada","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Japanese Red Cross Otsu Hospital  Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Takebayashi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Shiga General Hospital  Moriyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1794-2091","authenticated-orcid":false,"given":"Shogo","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Kobe City Medical Center General Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyomi","family":"Hamaguchi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Kyoto University Graduate School of Medicine  Kyoto Japan"},{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Kobe City Medical Center General Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; 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