{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:11:55Z","timestamp":1777579915206,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["23ck0106829h0001"],"award-info":[{"award-number":["23ck0106829h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We evaluated clinical and dosimetric outcomes of radiotherapy using two anterior oblique portals (AOP), to reduce the dose to the bilateral internal carotid arteries (CAs) and pharyngeal constrictor muscle (PCM) during early\u2010stage glottic cancer (ESGC) treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified patients with ESGC who underwent definitive radiotherapy between June 2014 and May 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 66 patients, 32 (48%) underwent radiotherapy using AOP, and the remaining underwent typical radiotherapy using parallel opposed lateral portals (POLP). The median follow\u2010up duration was 53\u2009months. No significant differences were observed in the 5\u2010year local failure (0%\/9.4%), progression\u2010free survival (90.6%\/90.8%), and overall survival (90.6%\/91.0%) rates between the two groups. The grade \u22652 acute mucositis incidence rate was significantly lower in the AOP group (44%\/85%). Radiotherapy using AOP maintained an adequate dose coverage to the target while markedly reducing the CAs and PCM doses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Radiotherapy with AOP resulted in favorable clinical and dosimetric outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27568","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T11:20:35Z","timestamp":1699356035000},"page":"239-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Accelerated <scp>three\u2010dimensional<\/scp> conformal radiotherapy for <scp>early\u2010stage<\/scp> glottic cancer in reducing dose to the internal carotid artery and pharyngeal constrictor muscles"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7822-2952","authenticated-orcid":false,"given":"Kento","family":"Tomizawa","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center Hospital East  Kashiwa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5231-6443","authenticated-orcid":false,"given":"Atsushi","family":"Motegi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center Hospital East  Kashiwa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Oyoshi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center Hospital East  Kashiwa 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