{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:10:06Z","timestamp":1747149006553,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T00:00:00Z","timestamp":1699660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The underlying factors that contribute to early radiotherapy (RT) termination are understudied, especially in the era of hypofractionated treatment regimens. In this retrospective investigation, we examined the characteristics and causes of premature RT terminations in senior adults (&gt;70\u2009years old) with oral cavity (OC) and laryngeal carcinomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hundred and eighty\u2010eight patients treated with RT\u2009\u00b1\u2009systemic therapy for OC and laryngeal cancer from 2017 to 2022 were identified. Premature termination was defined as completion of less than 95% of the prescribed RT. Logistic regression analysis was performed to examine factors predictive of premature termination, and survival was determined using the Kaplan\u2013Meier method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty patients (10.6%) experienced premature RT terminations. On regression analysis, ECOG score at initiation of RT was the only covariate studied to be independently associated with premature termination (OR 2.00, 95%CI: [1.21, 3.30], <jats:italic>p<\/jats:italic>\u2009=\u20090.007). Three\u2010year overall survival (49.1% vs. 77.3%) was significantly reduced in the termination cohort (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This analysis demonstrated over 1 in 10 patients had premature RT termination, which prognosticated inferior survival outcomes. Poor performance status may highlight patients at risk for premature termination and thus identify good candidates for hypofractionated protocols.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27570","type":"journal-article","created":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T10:04:10Z","timestamp":1699697050000},"page":"262-268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical predictors of premature radiotherapy terminations in senior adults with oral cavity and laryngeal carcinoma"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8511-8371","authenticated-orcid":false,"given":"Dylan J.","family":"Cooper","sequence":"first","affiliation":[{"name":"Department of Radiation Medicine Northwell Health Cancer Institute  Lake Success New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Travaglia","sequence":"additional","affiliation":[{"name":"Department of Pathology Northwell Health  New Hyde Park New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meytal","family":"Guller","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Northwell Health Cancer Institute  Lake Success New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wesley J.","family":"Talcott","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine Northwell Health Cancer Institute  Lake Success New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9007-3443","authenticated-orcid":false,"given":"Maged","family":"Ghaly","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine Northwell Health Cancer Institute  Lake Success New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4880-6172","authenticated-orcid":false,"given":"Brett A.","family":"Miles","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Northwell Health Cancer Institute  Lake Success New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Northwell Health Cancer Institute  Lake Success New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagashree","family":"Seetharamu","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Northwell Health Cancer Institute  New Hyde Park New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1668-2611","authenticated-orcid":false,"given":"Bhupesh","family":"Parashar","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine Northwell Health Cancer Institute  Lake Success New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,11]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Bureau UC.Demographic turning points for the United States: population projections for 2020 to 2060.https:\/\/www.census.gov\/library\/publications\/2020\/demo\/p25-1144.html. 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