{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:00:06Z","timestamp":1791669606518,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T00:00:00Z","timestamp":1702166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG6L0232"],"award-info":[{"award-number":["CMRPG6L0232"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to explore the prognostic utility of the preoperative platelet\u2010to\u2010albumin ratio (PAR) among patients with oral cavity squamous cell carcinoma (OSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed of 355 patients with surgically\u2010treated OSCC between 2008 and 2017. The optimal PAR cutoff for patient stratification was determined through X\u2010tile analysis. Prognostic variables for disease\u2010free survival (DFS) and overall survival (OS) were identified using Cox proportional hazards models. We developed a PAR\u2010based nomogram to predict personalized OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We determined the optimal PAR cutoff to be 7.45. A PAR of \u22657.45 was an independent negative prognostic factor for DFS and OS (hazard ratio\u2009=\u20091.748 and 2.386; <jats:italic>p<\/jats:italic>\u2009=\u20090.005 and <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, respectively). The developed nomogram demonstrates the practical utility of PAR and accurately predicts personalized OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The preoperative PAR is a promising and cost\u2010effective prognostic biomarker for patients with surgically\u2010treated OSCC; the PAR\u2010based nanogram accurately predicts OS for such patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27592","type":"journal-article","created":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T10:09:17Z","timestamp":1702202957000},"page":"386-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic utility of preoperative platelet\u2010to\u2010albumin ratio in surgically treated oral cavity cancer patients"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2313-0890","authenticated-orcid":false,"given":"Yao\u2010Te","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Chang Gung Memorial Hospital  Chiayi Taiwan"},{"name":"College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ku\u2010Hao","family":"Fang","sequence":"additional","affiliation":[{"name":"College of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6877-1579","authenticated-orcid":false,"given":"Ming\u2010Hsien","family":"Tsai","sequence":"additional","affiliation":[{"name":"College of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Chang Gung Memorial Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Hsuan","family":"Lai","sequence":"additional","affiliation":[{"name":"College of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Radiation Oncology Chang Gung Memorial Hospital  Chiayi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0556-5492","authenticated-orcid":false,"given":"Chien\u2010An","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Chang Gung Memorial Hospital  Chiayi Taiwan"},{"name":"College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Shao","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Chang Gung Memorial Hospital  Chiayi Taiwan"},{"name":"College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng\u2010He","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Chang Gung Memorial Hospital  Chiayi Taiwan"},{"name":"College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Ta","family":"Liao","sequence":"additional","affiliation":[{"name":"College of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Jan","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Ming","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Chang Gung Memorial Hospital  Chiayi Taiwan"},{"name":"College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan I.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Chang Gung Memorial Hospital  Chiayi Taiwan"},{"name":"College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9826-284X","authenticated-orcid":false,"given":"Yi\u2010Chan","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Medicine Chang Gung University  Taoyuan 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