{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:14:08Z","timestamp":1790144048312,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203680"],"award-info":[{"award-number":["82203680"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2021\u2010MS\u2010176"],"award-info":[{"award-number":["2021\u2010MS\u2010176"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to explore preliminary the performance of radiomics machine learning models based on multimodal MRI to predict the risk of cervical lymph node metastasis (CLNM) for oral tongue squamous cell carcinoma (OTSCC) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 400 patients were enrolled in this study and divided into six groups according to the different combinations of MRI sequences. Group I consisted of patients with T1\u2010weighted images (T1WI) and FS\u2010T2WI (fat\u2010suppressed T2\u2010weighted images), group II consisted of patients with T1WI, FS\u2010T2WI, and contrast enhanced MRI (CE\u2010MRI), group III consisted of patients with T1WI, FS\u2010T2WI, and T2\u2010weighted images (T2WI), group IV consisted of patients with T1WI, FS\u2010T2WI, CE\u2010MRI, and T2WI, group V consisted of patients with T1WI, FS\u2010T2WI, T2WI, and apparent diffusion coefficient map (ADC), and group VI consisted of patients with T1WI, FS\u2010T2WI, CE\u2010MRI, T2WI, and ADC. Machine learning models were constructed. The performance of the models was compared in each group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The machine learning model in group IV including T1WI, FS\u2010T2WI, T2WI, and CE\u2010MRI presented best prediction performance, with AUCs of 0.881 and 0.868 in the two sets. The models with CE\u2010MRI performed better than the models without CE\u2010MRI(I vs. II, III vs. IV, V vs. VI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The radiomics machine learning models based on CE\u2010MRI showed great accuracy and stability in predicting the risk of CLNM for OTSCC patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27605","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T14:57:14Z","timestamp":1702911434000},"page":"513-527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The application of radiomics machine learning models based on multimodal <scp>MRI<\/scp> with different sequence combinations in predicting cervical lymph node metastasis in oral tongue squamous cell carcinoma patients"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5251-2767","authenticated-orcid":false,"given":"Sheng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Oromaxillofacial\u2010Head and Neck Surgery, Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oromaxillofacial\u2010Head and Neck Surgery, Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Oromaxillofacial\u2010Head and Neck Surgery, Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingzhou","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Oromaxillofacial\u2010Head and Neck Surgery, Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Oromaxillofacial\u2010Head and Neck Surgery, Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases  Shenyang 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