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Hunter Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002784","name":"Canada Excellence Research Chairs, Government of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002784","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head & Neck"],"published-print":{"date-parts":[[2024,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Measuring dysphagia\u2010related patient\u2010reported outcomes (PROs) in Head and Neck Cancer (HNC) patients is challenging due to dysphagia's multidimensional impact, causing inconsistency in outcome reporting. To address this issue, this study derived a consensus\u2010based core outcome set (COS) for patient\u2010reported dysphagia in HNC clinical trials where swallowing is a primary or secondary endpoint.<\/jats:p><\/jats:sec>Methods<\/jats:title>A sample of HNC clinicians, researchers, patients, and caregivers participated in a 2\u2010Round Delphi technique. A Delphi survey, containing a comprehensive list of dysphagia\u2010related PROs, was developed. In Round 1, participants rated item importance on a 5\u2010point scale. Items rated \u22654 by >70% advanced to Round 2, where a consensus meeting addressed items with varied opinions, and the Delphi survey with remaining items was completed. Items rated \u22654 by >70% formed the final COS.<\/jats:p><\/jats:sec>Results<\/jats:title>Forty\u2010five participants from nine countries were recruited. After Round 1, 40 items were excluded and 64 advanced to Round 2. After Round 2, a 7\u2010outcome COS was established, comprising the domains of dysphagia symptoms, health status and quality of life.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This study achieved consensus among HNC stakeholders on essential dysphagia PROs for HNC clinical trials. It is advisable to include these 7\u2010core concepts in clinical trials involving people with HNC to facilitate treatment comparisons and data synthesis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27626","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T02:06:11Z","timestamp":1704938771000},"page":"831-848","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A c<\/b>ore outcome set for patient\u2010reported dysphagia for use in head and neck cancer clinical trials: An international multistakeholder Delphi study"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8953-8373","authenticated-orcid":false,"given":"Beatrice","family":"Manduchi","sequence":"first","affiliation":[{"name":"Rehabilitation Sciences Institute, University of Toronto Toronto Ontario Canada"},{"name":"Department of Speech\u2010Language Pathology University of Toronto Toronto Ontario Canada"},{"name":"The Swallowing Lab University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret I.","family":"Fitch","sequence":"additional","affiliation":[{"name":"Bloomberg Faculty of Nursing University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolie G.","family":"Ringash","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Princess Margaret Cancer Centre University of Toronto Toronto Ontario Canada"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Howell","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre Toronto Ontario Canada"},{"name":"Faculty of Nursing University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3298-7714","authenticated-orcid":false,"given":"Rosemary","family":"Martino","sequence":"additional","affiliation":[{"name":"Rehabilitation Sciences Institute, University of Toronto Toronto Ontario Canada"},{"name":"Department of Speech\u2010Language Pathology University of Toronto Toronto Ontario Canada"},{"name":"The Swallowing Lab University of Toronto Toronto Ontario Canada"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Toronto Toronto Ontario Canada"},{"name":"Krembil Research Institute, University Health Network Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2007.08.006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25412"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.06.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26638"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-022-07322-w"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-3618-7"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2013.6.3.117"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgh038"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.04.007"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/PROM.S129012"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.10.015"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-016-9741-7"},{"key":"e_1_2_9_15_1","unstructured":"Manduchi B Che Z Ringash J Fitch M Howell D Martino M.\u201cPatient\u2010reported outcome measures for dysphagia in head and neck cancer: a systematic review and appraisal of content validity and internal structure\u201d.Manuscript submitted for publication."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-019-10005-0"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.01.097"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-1978-4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-8-39"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-036562"},{"key":"e_1_2_9_21_1","unstructured":"Cochrane Community Blog.Cochrane and COMET: Working Together to Improve Core Outcome Sets.2017. 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