{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:10:15Z","timestamp":1747149015080,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271184"],"award-info":[{"award-number":["82271184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To summarize the clinical characteristics and prognosis of children with nasolabial fold rhabdomyosarcoma (RMS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of children treated for nasolabial fold RMS from January 2014 to September 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 21 patients with nasolabial fold RMS, 90.48% were alveolar subtype, in which PAX3\/7\u2010FOXO1 fusion positive accounted for 87.5%. Ten patients (47.62%) had nodals invasion. Almost all patients received comprehensive treatment (chemotherapy [100%], radiation therapy [100%], and surgery [95.24%]). The median follow\u2010up time was 34.3\u2009months. The 3\u2010year overall survival (OS) and event\u2010free survival (EFS) was 67.7%\u2009\u00b1\u200914.1% and 42.1%\u2009\u00b1\u200913.5%, respectively. Four patients had regional lymph node relapse (NR), all in the ipsilateral submandibular lymph node region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Majority of the patients with RMS in the nasolabial fold area were alveolar subtype and had positive PAX3\/7\u2010FOXO1 gene fusion. In addition, the nasolabial fold RMS had a high probability of regional lymph node metastasis in the submandibular area. To maintain the facial aesthetics and functions, the surgical area for nasolabial fold RMS is often very conservative and restricted. This could be one of the contributors for the poor prognosis of nasolabial fold RMS beside its worse pathological subtype and gene fusion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27637","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T08:27:31Z","timestamp":1705048051000},"page":"905-914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of nasolabial fold rhabdomyosarcoma in children: A single\u2010institution experience"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5318-6393","authenticated-orcid":false,"given":"Ge","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Beijing Children's Hospital, Capital Medical University, National Center for Children's Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nian","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Beijing Children's Hospital, Capital Medical University, National Center for Children's Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Beijing Children's Hospital, Capital Medical University, National Center for Children's Health  Beijing China"},{"name":"Department of Beijing Key Laboratory for Pediatric Diseases of Otolaryngology \u2013 Head and Neck Surgery Beijing Children's Hospital, Capital Medical University, National Center for Children's Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Hematology 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