{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T05:57:57Z","timestamp":1774504677342,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006181","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado da Bahia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the association between tooth loss and oral potentially malignant disorders and oral squamous cell carcinoma, focusing on epidemiological factors and genetic variants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case\u2013control study, including histologically confirmed oral potentially malignant disorders and oral squamous cell carcinoma cases and healthy controls. Unadjusted and adjusted odds ratios for this association were calculated. Single\u2010nucleotides polymorphisms were tested for individuals with and without missing teeth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Case individuals were more edentulous while controls had fewer missing teeth (<jats:italic>p<\/jats:italic>\u2009=\u20090.006). There was an increased risk for the outcomes associated with edentulism (OR\u2009=\u20096.95, <jats:italic>p<\/jats:italic>\u2009=\u20090.000), even after adjustments for educational level (OR\u2009=\u20094.7, <jats:italic>p<\/jats:italic>\u2009=\u20090.034) and smoking habits (OR\u2009=\u20095.01, <jats:italic>p<\/jats:italic>\u2009=\u20090.022). Among individuals with tooth loss, rs1533767 (<jats:italic>WNT11<\/jats:italic>), rs3923087, and rs11867417 (<jats:italic>AXIN2)<\/jats:italic> were associated with the outcomes (OR\u2009=\u20091.67, <jats:italic>p<\/jats:italic>\u2009=\u20090.03, OR\u2009=\u20090.53, <jats:italic>p<\/jats:italic>\u2009=\u20090.05, and OR\u2009=\u20090.42, <jats:italic>p<\/jats:italic>\u2009=\u20090.00, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tooth loss could increase the risk for oral potentially malignant disorders and oral squamous cell carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27648","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T09:54:01Z","timestamp":1706608441000},"page":"1417-1427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetic and environmental contributions for the relationship between tooth loss and oral potentially malignant disorders and oral squamous cell carcinoma"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9314-6970","authenticated-orcid":false,"given":"Adriana M.","family":"da Silva","sequence":"first","affiliation":[{"name":"Department of Health, Public Health PhD Program Universidade Estadual de Feira de Santana  Feira de Santana Brazil"},{"name":"Department of Oral and Craniofacial Sciences University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle M. L.","family":"Falc\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Health, Public Health PhD Program Universidade Estadual de Feira de Santana  Feira de Santana Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria S.","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Health, Public Health PhD Program Universidade Estadual de Feira de Santana  Feira de Santana Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre R.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniofacial Sciences University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization.Oral health; 2023.https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/oral\u2010health#:~:text=Edentulism%20(total%20tooth%20loss)&text=The%20estimated%20global%20average%20prevalence aged%2020%20years%20or%20older. 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