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We sought to explore the demographics, clinical characteristics, treatment methods, and outcomes of SDH\u2010mutated HNPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Databases were systematically searched. Pooled event ratio and relative 95% confidence intervals were calculated for dichotomous outcomes. Meta\u2010regression was performed. Cochran's <jats:italic>Q<\/jats:italic> test and <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> test assessed heterogeneity. Funnel plot and Egger's regression test assessed publication bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010two studies with 8849 patients were included. Meta\u2010regression revealed a significant correlation between multifocality and SDHD mutations (0.03\u2009\u00b1\u20090.006, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and between distant metastases and SDHB mutations (0.06\u2009\u00b1\u20090.023, <jats:italic>p<\/jats:italic>\u2009=\u20090.008). There was no correlation between sex, age, tumor size, or familial occurrences and SDH\u2010related mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Multifocality of HNPs correlates with the SDHD mutational subtype, and metastases correlate with the SDHB subtype. Knowledge of HNP phenotypes associated with SDH\u2010related mutations has the potential to influence the management approach to such HNPs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27652","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T07:44:22Z","timestamp":1706255062000},"page":"1795-1808","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Succinate dehydrogenase mutations in head and neck paragangliomas: A systematic review and meta\u2010analysis of individual patients' data"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2049-1746","authenticated-orcid":false,"given":"Elizabeth S.","family":"Koh","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas","family":"Dabsha","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Rahouma","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Zappi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5279-9753","authenticated-orcid":false,"given":"Yashes","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Hickner","sequence":"additional","affiliation":[{"name":"Samuel J. 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