{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T12:38:07Z","timestamp":1771072687424,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772852"],"award-info":[{"award-number":["81772852"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972496"],"award-info":[{"award-number":["81972496"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effectiveness of radiotherapy and its association with second primary malignancies (SPMs) risk in major salivary gland carcinomas (MSGCs) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cohort 1 included 7274 surgically treated MSGC patients from the Surveillance, Epidemiology, and End Results database, assessing the effectiveness of radiotherapy. Cohort 2 (<jats:italic>n<\/jats:italic>\u2009=\u20094213) comprised patients with \u22655\u2010year survival in Cohort 1 to study SPMs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Radiotherapy decreased overall survival in MSGCs patients, but improved it in high\u2010grade MSGCs. Cumulative SPMs incidences at 25\u2009years were 16.5% in the radiotherapy (RT) group compared to 14.5% in the non\u2010radiotherapy (NRT) group. For second head and neck carcinomas (SHNCs), incidences were 3.4% in RT versus 1.6% in NRT. Radiotherapy increased the relative risks of tumors, particularly SHNCs (RR\u2009=\u20091.78). The 10\u2010year OS rates of SHNCs after radiotherapy were significantly lower.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Radiotherapy improves survival in advanced\u2010stage MSGCs but increases the risk of developing SPMs, particularly SHNCs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27664","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T09:09:04Z","timestamp":1706519344000},"page":"1201-1209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness and risk of second primary malignancies after radiotherapy in major salivary gland carcinomas: A retrospective study using <scp>SEER<\/scp> database"],"prefix":"10.1002","volume":"46","author":[{"given":"Yuan","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital  Shanghai 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