{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:10:21Z","timestamp":1747149021022,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:00:00Z","timestamp":1708128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The effect of radiotherapy waiting time after last induction chemotherapy (IC\u2010RT) on prognosis of patients with locally advanced nasopharyngeal carcinoma (LANPC) needs further discussion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three hundred and six patients with LANPC diagnosed pathologically by induction chemotherapy (IC) and radiotherapy (RT) from 2013 to 2018 were selected for this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The IC\u2010RT was a risk factor for the post\u2010treatment progression of LANPC (OR\u2009=\u20091.017 95%CI: 1.003\u20131.031), For patients with LANPC, the IC\u2010RT\u2009&gt;\u200940\u2009days significantly reduced 5\u2010year PFS (70% vs. 55%; <jats:italic>p<\/jats:italic>\u2009=\u20090.0012), 5\u2010year OS (84% vs. 73%; <jats:italic>p<\/jats:italic>\u2009=\u20090.028), 5\u2010year DMFS (80% vs. 66%; <jats:italic>p<\/jats:italic>\u2009=\u20090.003), 5\u2010year LRFS (77% vs. 67%; <jats:italic>p<\/jats:italic>\u2009=\u20090.012). Indicating that patients with stage IVa who IC\u2010RT\u2009&gt;\u200940\u2009days were found to be a significant predictor of aggravated PFS (HR\u2009=\u20092.69; 95%CI: 1.57\u20134.6), OS (HR\u2009=\u20092.55; 95%CI: 1.29\u20135.03), DMFS (HR\u2009=\u20093.07; 95%CI: 1.64\u20135.76) and LRFS (HR\u2009=\u20092.26; 95%CI: 1.21\u20134.21).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prognosis of patients will be adversely affected if the IC\u2010RT exceeds 40 days, especially for stage IVa patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27680","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T08:14:38Z","timestamp":1708157678000},"page":"1189-1200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of waiting time for radiotherapy after last induction chemotherapy on prognosis of locally advanced nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4500-9897","authenticated-orcid":false,"given":"Kui\u2010Xuan","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Radiotherapy The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center)  Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Radiology The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center)  Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Min","family":"E","sequence":"additional","affiliation":[{"name":"Department of General Surgery The Second Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu 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