{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T21:49:50Z","timestamp":1776376190283,"version":"3.51.2"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Traditionally, patients undergoing free flap reconstruction for oral cavity defects have been given nothing by mouth for 6\u201314\u2009days post\u2010operatively due to concern for orocutaneous fistula development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multiple databases were screened for studies assessing the rate of orocutaneous fistula formation in early (\u22645\u2009days) versus late (&gt;5\u2009days) feeding groups following oral cavity free flap reconstruction. Fixed\u2010 and random\u2010effects meta\u2010analyses were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One randomized controlled trial, one prospective cohort, and three retrospective cohort studies were included. The early feeding group displayed no significant increase in orocutaneous fistula formation (RD\u2009=\u2009\u22120.02, <jats:italic>p<\/jats:italic>\u2009=\u20090.06) or free flap failure (RD\u2009=\u2009\u22120.01, <jats:italic>p<\/jats:italic>\u2009=\u20090.39), with a significantly shorter hospital length of stay (mean difference [days]\u2009=\u2009\u22122.43, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While further prospective trials are necessary, initiation of oral intake before post\u2010operative day 5 may be appropriate in properly selected patients following oral reconstruction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27684","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T05:23:26Z","timestamp":1709097806000},"page":"1224-1233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early feeding after free flap reconstruction of the oral cavity: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6900-4734","authenticated-orcid":false,"given":"Joshua","family":"Barlow","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zara","family":"Sragi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New 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