{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T04:43:28Z","timestamp":1770007408982,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with nonlocalizing hyperparathyroidism pose a significant challenge to surgeons when undergoing neck exploration for parathyroidectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated 536 patients that had parathyroidectomy for primary hyperparathyroidism (PHPT) from 2005 to 2018 at a single tertiary academic center, and 155 (29%) had standard nonlocalizing preoperative imaging (negative ultrasound and sestamibi scans).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were a total of 102 (66%) non\u2010ectopic single adenomas in the nonlocalizing group and 325 (85%) single adenomas in the localizing group. There was no significant difference (<jats:italic>p<\/jats:italic>\u2009=\u20090.09) in adenoma quadrant between localizing and nonlocalizing single adenomas, but the most common location in both groups was right inferior. Patients with nonlocalizing scans were more likely to have double adenomas (21% vs. 9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), ectopic glands (10% vs. 5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.052), and multi\u2010gland disease (13% vs. 8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Nonlocalizing PHPT patients experienced similar cure and complication rates as localizing PHPT, but required more bilateral explorations and increased operative time.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27686","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T09:54:52Z","timestamp":1708077292000},"page":"1788-1794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Surgery for nonlocalizing hyperparathyroidism in high volume center"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5508-3147","authenticated-orcid":false,"given":"Austin B.","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Loma Linda University Health  Loma Linda California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethan","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Loma Linda University Health  Loma Linda California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Alfred A.","family":"Simental","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Loma Linda University Health  Loma Linda California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Loma Linda University Health  Loma Linda California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-4022"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199204000-00002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2010.08.002"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.10.005"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs-20-611"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-022-06556-3"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2009.05.029"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1870-5"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10002-1155"},{"issue":"5","key":"e_1_2_11_11_1","first-page":"551","article-title":"Location of parathyroid adenomas: 7\u2010year experience","volume":"39","author":"Marzouki HZ","year":"2010","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1429-x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1412-0"},{"issue":"2","key":"e_1_2_11_14_1","first-page":"36","article-title":"Recommendations after non\u2010localizing sestamibi and ultrasound scans in primary hyperparathyroid disease: order more scans or explore surgically?","volume":"54","author":"Hoda NE","year":"2013","journal-title":"J Miss State Med Assoc"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.143.4.335"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25456"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.03.021"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000227957.06529.22"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2009.06.043"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.07.028"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1507-0"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816630711"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.27686","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T11:28:42Z","timestamp":1731497322000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.27686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,16]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/hed.27686"],"URL":"https:\/\/doi.org\/10.1002\/hed.27686","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,16]]},"assertion":[{"value":"2023-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}