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A systematic review was performed using multiple databases. An inverse\u2010variation, random\u2010effects model was used to perform the meta\u2010analysis to evaluate the effect of sarcopenia on severe treatment toxicity and poor treatment tolerance. Sixteen observational studies, including 3187 patients with HNC, were analyzed. The combined odds ratio (OR) for severe treatment toxicity and tolerance was 2.22 (95%CI 1.50\u20133.29) and 1.40 (95%CI 0.84\u20132.32), respectively. The effect of sarcopenia on short\u2010term severe treatment toxicity was similar with upfront surgery (OR 2.03, 95%CI 1.22\u20133.37) and definitive radiotherapy (OR 2.24, 95%CI 1.18\u20134.27) Patients with sarcopenia are more than twice as likely to suffer a short\u2010term treatment\u2010related toxicity when undergoing curative\u2010intent HNC treatment.<\/jats:p>","DOI":"10.1002\/hed.27688","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T05:36:22Z","timestamp":1707888982000},"page":"1500-1509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Sarcopenia predicts short\u2010term treatment\u2010related toxicity in patients undergoing curative\u2010intent therapy for head and neck cancer: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8880-805X","authenticated-orcid":false,"given":"Marco 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