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The miRNAs genes affected by CNAs were evaluated based on their expression patterns and subjected to pathway enrichment analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Across the groups, we found 216 CNAs affecting 2261 miRNA genes, with 117 in PA, 59 in RPA, 846 in residual PA, and 2555 in CXPA. The chromosome 8 showed higher involvement in altered miRNAs in PAs and CXPA patients. Six miRNA genes were shared among all groups. Additionally, miR\u201021, miR\u2010455\u20103p, miR\u2010140, miR\u2010320a, miR\u2010383, miR\u2010598, and miR\u2010486 were prominent CNAs found and is implicated in carcinogenesis of several malignant tumors. These miRNAs regulate critical signaling pathways such as aerobic glycolysis, fatty acid biosynthesis, and cancer\u2010related pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study was the first to explore CNAs in miRNA\u2010encoding genes in the PA\u2010CXPA sequence. 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