{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:40:03Z","timestamp":1790174403594,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An international multidisciplinary panel of experts aimed to provide consensus guidelines describing the optimal intratumoral and intranodal injection of NBTXR3 hafnium oxide nanoparticles in head and neck squamous cell carcinoma (HNSCC) of the oral cavity, oropharynx, and cervical lymph nodes and to review data concerning safety, feasibility, and procedural aspects of administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Delphi method was used to determine consensus. A 4\u2010member steering committee and a 10\u2010member monitoring committee wrote and revised the guidelines, divided into eight sections. An independent 3\u2010member reading committee reviewed the recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After two rounds of voting, strong consensus was obtained on all recommendations. Intratumoral and intranodal injection was deemed feasible. NBTXR3 volume calculation, choice of patients, preparation and injection procedure, potential side effects, post injection, and post treatment follow\u2010up were described in detail.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Best practices for the injection of NBTXR3 were defined, thus enabling international standardization of intratumoral nanoparticle injection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27739","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T03:13:46Z","timestamp":1712805226000},"page":"1253-1262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["International guidelines for intratumoral and intranodal injection of <scp>NBTXR3<\/scp> nanoparticles in head and neck cancers"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9448-3757","authenticated-orcid":false,"given":"Xavier","family":"Liem","sequence":"first","affiliation":[{"name":"Department of Radiotherapy\u2010Brachytherapy Unicancer\u2010Oscar Lambret Regional Cancer Center  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"de Ba\u00e8re","sequence":"additional","affiliation":[{"name":"Interventional Radiology Unit Institut Gustave Roussy  Villejuif France"},{"name":"Universit\u00e9 Paris\u2010Saclay, UFR M\u00e9decine Le Kremlin\u2010Bic\u00eatre  Le Kremlin Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar I.","family":"Vivar","sequence":"additional","affiliation":[{"name":"Global Medical Affairs Department Nanobiotix  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanguy Y.","family":"Seiwert","sequence":"additional","affiliation":[{"name":"Head and Neck Cancer Center Johns Hopkins University Medical Center  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colette","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of North Carolina (UNC) Medical Center  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"P\u00e1pai","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hungarian Defense Forces Military Hospital\u2010Honved Hospital  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Moreno","sequence":"additional","affiliation":[{"name":"START Madrid\u2010FJD Phase I Clinical Trials Unit Fundaci\u00f3n\u2010Jim\u00e9nez D\u00edaz University Hospital  Madrid 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue S.","family":"Yom","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of California San Francisco (UCSF) Medical Center  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bossi","sequence":"additional","affiliation":[{"name":"Medical Oncology, Department of Medical and Surgical Specialties, Radiological Sciences, Public Health University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Ferris","sequence":"additional","affiliation":[{"name":"UPMC Hillman Cancer Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor G.","family":"Hackman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of North Carolina (UNC) Medical Center  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9772-4686","authenticated-orcid":false,"given":"Christophe","family":"Le Tourneau","sequence":"additional","affiliation":[{"name":"Department of Drug Development and Innovation D3i, Institut Curie Paris\u2010Saclay University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"ENT Surgical and Medical Service, Hospital Center of Valenciennes (CHV)  Valenciennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgical Oncology PSL University, Institut Curie  Paris 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