{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:27:50Z","timestamp":1786372070323,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RC\u20102024\u20102790136"],"award-info":[{"award-number":["RC\u20102024\u20102790136"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this systematic review is to analyze epidemiology, clinical presentation, histopathological features, treatment and oncological outcomes in laryngeal mucoepidermoid cancer (MEC) in order to improve the knowledge on the management of such a rare malignant neoplasm. Specifically, authors highlight patients' and tumors' features about local, regional, and distant recurrence of disease. PRISMA 2020 guidelines were applied in this systematic literature review. A computerized search was performed using the Embase\/Pubmed, Scopus, and Cochrane databases, for articles published from 1971 to December 2023. A descriptive and univariate analysis including selected papers with low or intermediate risk of bias was performed. Twenty\u2010seven papers (11 case series and 16 case reports) were included in this review. Fifty\u2010six patients were included in the analyses, with a mean age of 56.7\u2009years; 84% of them were males. Most patients (86%) underwent a primary surgical approach. Clinical stage was reported as follows: early stage (26 patients) and locally advance and advanced stage (19 patients). Overall survival (OS) and disease\u2010free survival (DFS) at 2\u2009years was 80% and 78%, respectively. The mean time to local recurrence was 18.7\u2009months (range 8\u201336\u2009months). The survival after recurrence is about 85% and 70% at 5\u2009years, respectively. The mean time of lymph node recurrence was 14.7\u2009months (range 7\u201319\u2009months). Finally, the mean time of distant recurrence was 15\u2009months (range 7\u201336\u2009months) with a poor prognosis: all patients died due to the disease in a range of 0\u20137\u2009months after metastasis evidence. Laryngeal MEC is a rare neoplasm of minor salivary glands in the larynx. No guidelines or indications about the management of this neoplasm are reported in the literature. The lower incidence of regional recurrence of the disease and the better OS and DFS underline how the prognosis of MEC is more favorable respect to other malignant histotypes.<\/jats:p>","DOI":"10.1002\/hed.27767","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T07:45:25Z","timestamp":1712648725000},"page":"1822-1834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Analysis of local, regional, and distant recurrence of disease in mucoepidermoid tumors of larynx: A systematic review"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5600-3938","authenticated-orcid":false,"given":"Francesco","family":"Chiari","sequence":"first","affiliation":[{"name":"Otolaryngology and Audiology, IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna 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