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The L3 skeletal muscle index (SMI) is often used to assess sarcopenia and cachexia but is infrequently able to be measured in this population. Masseter muscle thickness (MT) may serve as an alternative predictor of cachexia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>SMI and MT were calculated from 20 trauma (CTRL) and 40 cachectic (CA\u2010CX) and non\u2010cachectic (CA\u2010NCX) head and neck cancer patients. Area Under the Curve of the Receiver Operating Characteristics (AUC\u2010ROC) analysis was performed for SMI and MT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both SMI and MT were significantly decreased in CA\u2010CX patients (vs. CA\u2010NCX mean difference \u221219.5\u2009cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup> and \u22122.06\u2009mm, respectively) and significant predictors of CA\u2010CX (AUC\u2009=\u20090.985 and 0.805, respectively). When analyzed by sex, the same findings were observed for MT in males and trended toward significance in females.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with SMI, MT is a good alternative prognostic biomarker to determine CA\u2010CX status in HNC patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27789","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T11:43:42Z","timestamp":1714045422000},"page":"2678-2686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Masseter muscle thickness is predictive of cancer cachexia in patients with head and neck cancer"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0138-9199","authenticated-orcid":false,"given":"Juli\u00e1n","family":"Balanta\u2010Melo","sequence":"first","affiliation":[{"name":"Department of Anatomy, Cell Biology &amp; Physiology Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Department of Prosthodontics Universidad del Valle School of Dentistry  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9219-285X","authenticated-orcid":false,"given":"Alexander J.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9018-7838","authenticated-orcid":false,"given":"Leah J.","family":"Novinger","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Colorado Anschutz Medical Campus  Aurora Colorado USA"},{"name":"Comprehensive Cancer Center University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3235-1871","authenticated-orcid":false,"given":"Andrea","family":"Bonetto","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Colorado Anschutz Medical Campus  Aurora Colorado USA"},{"name":"Comprehensive Cancer Center University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(10)70218\u20107"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27072"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14749"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100040\u20101701696"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010018\u20100753\u2010z"},{"key":"e_1_2_10_7_1","volume-title":"AJCC Cancer Staging Manual","author":"Amin MB","year":"2016"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0251455"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3352\/jeehp.2021.18.17"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430\u2010017\u20100034\u20105"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24672"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2016.1277263"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2012.45.2722"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2020.1869792"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.18060\/24742"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28616"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2019.04.023"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10040574"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820973232"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.530"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30668"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.6339"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010020\u201006273\u20104"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12529"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/cmar.s329581"},{"key":"e_1_2_10_26_1","doi-asserted-by":"crossref","unstructured":"HayashiN SatoY FujiwaraY et al.Association between cancer cachexia and prognosis in patients with head and neck squamous cell carcinoma who received chemoradiotherapy.2021. doi:10.21203\/rs.3.rs\u2010695263\/v1","DOI":"10.21203\/rs.3.rs-695263\/v1"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims\u201021\u201043"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2021.07.020"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2023.110939"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13362"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/ta.0000000000001297"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs\u201076\u2009634\/v1"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5422"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13072401"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.2174\/1745017901814010723"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11091587"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741\u20102358.1993.tb00074.x"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041\u20101626.2011.0088.x"}],"container-title":["Head &amp; 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