{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:36:49Z","timestamp":1771306609262,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tubarial glands are a new organ at risk for head and neck cancer radiation therapy (RT). We aimed to study the feasibility of sparing them using intensity\u2010modulated radiation therapy (IMRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Tubarial glands were delineated for 17 patients with oropharyngeal carcinoma receiving definitive RT, and treatment plans were re\u2010optimized to spare dose to the tubarial glands while maintaining target coverage. A paired <jats:italic>t<\/jats:italic> test was performed to compare the mean dose of tubarial glands and target coverage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The difference in mean doses was 4.9 and 7.0\u2009Gy for the ipsilateral and contralateral tubarial glands, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The mean dose to tubarial gland was \u226439\u2009Gy in 35% versus 47% (ipsilateral) and 70% versus 100% (contralateral) in clinical and re\u2010optimized plans, respectively. Re\u2010optimized ipsilateral tubarial gland mean\u2009\u226439\u2009Gy was achieved more commonly in patients with base of tongue versus tonsil primaries (86% vs. 20%, <jats:italic>p<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This pilot study demonstrates the dosimetric feasibility of tubarial gland sparing with IMRT. Dosimetric constraints need to be determined with larger studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27791","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T09:12:08Z","timestamp":1715764328000},"page":"1582-1588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tubarial gland sparing with intensity modulated radiation therapy for oropharyngeal cancers: A pilot study of dosimetric feasibility"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5203-7989","authenticated-orcid":false,"given":"Sreenija","family":"Yarlagadda","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Miami Cancer Institute, Baptist Health South Florida  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"McAllister","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Miami Cancer Institute, Baptist Health South Florida  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy E.","family":"Rzepczynski","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Miami Cancer Institute, Baptist Health South Florida  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0416-8612","authenticated-orcid":false,"given":"Tugce","family":"Kutuk","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Miami Cancer Institute, Baptist Health South Florida  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah S.","family":"Kalman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Miami Cancer Institute, Baptist Health South Florida  Miami Florida USA"},{"name":"Department of Radiation Oncology Herbert Wertheim College of Medicine, Florida International University  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)01550\u20106"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.02.211"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10129"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0360\u20103016(03)01437\u20108"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.12.033"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(09)70231\u20101"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(10)70290\u20104"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24263"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2020.09.034"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meddos.2022.03.001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27021"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.10.010"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.07.041"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.12.016"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.07.1734"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.10.032"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.09.018"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.27791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T11:29:14Z","timestamp":1731497354000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.27791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,15]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/hed.27791"],"URL":"https:\/\/doi.org\/10.1002\/hed.27791","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,15]]},"assertion":[{"value":"2024-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}