{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:38:09Z","timestamp":1772995089447,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T00:00:00Z","timestamp":1715040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T00:00:00Z","timestamp":1715040000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Despite advances in treatment, residual or recurrent tumors after definitive (chemo) radiotherapy for laryngeal and hypopharyngeal squamous cell carcinoma (SCC) remain a challenge in clinical management and require accurate and timely detection for optimal salvage therapy. This study aimed to compare the diagnostic value of Fluorine 18 (\n 18<\/jats:sup>\n F) fluorodeoxyglucose (FDG) positron emission tomography (PET)\/computed tomography (CT) and diffusion\u2010weighted magnetic resonance imaging (DW\u2010MRI) in detecting residual or recurrent tumors after definitive (chemo) radiotherapy for laryngeal and hypopharyngeal SCC.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A prospective study was conducted on 30 patients who presented with new symptoms after definitive (chemo) radiotherapy for laryngeal (\n n<\/jats:italic>\n \u2009=\u200921) and hypopharyngeal (\n n<\/jats:italic>\n \u2009=\u20099) carcinoma. Both\n 18<\/jats:sup>\n F\u2010FDG PET\/CT and DW\u2010MRI were performed and histopathologic analysis served as the standard of reference.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Histopathology showed 20 patients as positive and 10 as negative for tumors.\n 18<\/jats:sup>\n F\u2010FDG PET\/CT detected all tumors correctly but was falsely positive in one case. DW\u2010MRI detected tumors in 18 out of 20 positive patients and correctly excluded tumors in all negative patients. The sensitivity and specificity of\n 18<\/jats:sup>\n F\u2010FDG PET\/CT were 100% and 90%, respectively, while the values for DW\u2010MRI were 90% and 100%, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The study concludes that\n 18<\/jats:sup>\n F\u2010FDG PET\/CT is slightly superior to DW\u2010MRI in detecting residual or recurrent tumors after definitive (chemo) radiotherapy for laryngeal and hypopharyngeal SCC. The combined use of\n 18<\/jats:sup>\n F\u2010FDG PET\/CT and DW\u2010MRI can potentially improve specificity in therapy response evaluation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hed.27796","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T04:19:36Z","timestamp":1715055576000},"page":"2284-2291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnostic value of\n \n 18<\/sup>\n F\u2010FDG PET\n <\/scp>\n \/\n CT<\/scp>\n versus diffusion\u2010weighted\n MRI<\/scp>\n in detection of residual or recurrent tumors after definitive (chemo) radiotherapy for laryngeal and hypopharyngeal squamous cell carcinoma: A prospective study"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8968-4271","authenticated-orcid":false,"given":"Soung Yung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Radiology Spital Muri Muri Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Crook","sequence":"additional","affiliation":[{"name":"Department of Radiology Spital Muri Muri Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Rosskopf","sequence":"additional","affiliation":[{"name":"BKH G\u00fcnzburg G\u00fcnzburg Germany"},{"name":"Department of Diagnostic and Interventional Radiology University Hospital Ulm Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1913-0027","authenticated-orcid":false,"given":"Jung\u2010Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Life Science University of Seoul Seoul Republic of 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