{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:08:26Z","timestamp":1747148906296,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transoral surgical resectability (TOS) is a prognostic factor for patients with HPV+ T1\u20102 oropharyngeal squamous cell carcinoma (OPSCC) disease undergoing radiotherapy (RT), but it is unclear whether this holds for HPV\u2010negative (HPV\u2010) patients. We aimed to compare outcomes of potential TOS\u2010candidates vs. non\u2010TOS candidates, among patients who underwent RT\/CRT for early T\u2010stage HPV\u2010 OPSCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For patients treated with RT\/CRT for early T\u2010stage HPV\u2010negative OPSCC between 2014 and 2021, pretreatment imaging was reviewed by four head\u2010and\u2010neck surgeons, masked to clinical outcomes, to assess primary\u2010site suitability for TOS. Extracapsular extension (ECE) was assessed by a head\u2010and\u2010neck neuroradiologist. We compared outcomes based on surgical resectability relating to: (1) the primary site tumor alone, and (2) the primary site plus the absence\/presence of ECE (overall assessment). Kaplan\u2013Meier curves for overall survival (OS), disease\u2010specific survival (DSS), and progression\u2010free survival (PFS) were compared using the log\u2010rank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy patients were included in the analysis. The primary site was TOS\u2010favorable in 46\/70 (66%). Based on the overall assessment, 41\/70 (58.6%) were TOS\u2010favorable. The 3\u2010year OS, DSS and PFS for primary site TOS\u2010favorable versus unfavorable were OS: 76.9% versus 37.4%; DSS: 78.1% versus 46.2%, PFS: 69.9% versus 41.3%, (log\u2010rank test\u2009=\u20090.01, 0.03, 0.04; respectively). Additionally, patients with an overall assessment of TOS favorability demonstrated better survival outcomes compared with TOS\u2010unfavorable patients (OS: 77.3% vs. 46.2%; DSS: 78.2% vs. 56.5%, PFS: 72.3% vs. 42.1%, log\u2010rank test\u2009=\u20090.01, 0.04, 0.01; respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with TOS\u2010favorable HPV\u2010negative early T\u2010stage OPSCC have superior survival outcomes than TOS\u2010unfavorable patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27802","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T10:49:23Z","timestamp":1716461363000},"page":"2789-2797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes for potentially Resectable patients undergoing primary chemoradiation treatment for <scp>T1<\/scp>\u2013<scp>T2 HPV<\/scp> Negative oropharyngeal squamous cell carcinoma"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3140-883X","authenticated-orcid":false,"given":"Francisco","family":"Laxague","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Western Ontario  London Ontario Canada"},{"name":"Department of Head and Neck Surgery Hospital Aleman of Buenos Aires  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naif","family":"Fnais","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Western Ontario  London Ontario Canada"},{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Young","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Western Ontario  London Ontario Canada"},{"name":"Department of Otolaryngology Dongnam Institute of Radiological &amp; Medical Sciences  Busan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Western Ontario  London Ontario Canada"},{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe S.","family":"Mymryk","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Western Ontario  London Ontario Canada"},{"name":"Department of Microbiology &amp; Immunology University of Western Ontario  London Ontario Canada"},{"name":"Department of Oncology University of Western Ontario  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Western Ontario  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keng Yow","family":"Tay","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging University of Western Ontario  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging University of Western Ontario  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Theurer","sequence":"additional","affiliation":[{"name":"School of Communication Sciences and Disorders, Western University  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0760-980X","authenticated-orcid":false,"given":"Anthony C.","family":"Nichols","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Western Ontario  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9542-0627","authenticated-orcid":false,"given":"David A.","family":"Palma","sequence":"additional","affiliation":[{"name":"Department of Oncology University of Western Ontario  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_12_2_1","DOI":"10.1056\/NEJMoa0912217"},{"doi-asserted-by":"publisher","key":"e_1_2_12_3_1","DOI":"10.1016\/S1470-2045(10)70017-6"},{"doi-asserted-by":"publisher","key":"e_1_2_12_4_1","DOI":"10.1002\/cncr.29938"},{"key":"e_1_2_12_5_1","first-page":"1","article-title":"Novel strategies to effectively de\u2010escalate curative\u2010intent therapy for patients with hpv\u2010associated oropharyngeal cancer: current and future directions","volume":"40","author":"Price KAR","year":"2020","journal-title":"Am Soc Clin Oncol Educ 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Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.27802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T11:23:47Z","timestamp":1728905027000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.27802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,23]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/hed.27802"],"URL":"https:\/\/doi.org\/10.1002\/hed.27802","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"type":"print","value":"1043-3074"},{"type":"electronic","value":"1097-0347"}],"subject":[],"published":{"date-parts":[[2024,5,23]]},"assertion":[{"value":"2024-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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