{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T14:54:55Z","timestamp":1774968895439,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2017M611174"],"award-info":[{"award-number":["2017M611174"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ear and temporal bone squamous cell carcinoma (ETBSCC) is a rare and aggressive malignant tumor with minimal clinicopathological studies. The object of this study was to retrospectively evaluate the predictive effect of clinicopathological variables on the 5\u2010year overall survival (OS) rate of ETBSCC patients in a single tertiary medical center in Tianjin, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of 44 patients with diagnosed ETBSCC from December 2012 to August 2022 were retrospectively studied. Univariate and multivariate analysis were, respectively, performed for the assessment of clinicopathological predictors, including sex, age, history of chronic suppurative otitis media (CSOM), lesion side, diameter, the choice of surgical approach, parotidectomy, neck dissection, adjuvant therapies, T stage, lymph node metastasis, tumor grade, margin, perineural invasion (PNI), and Ki\u201067 index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen females and 27 males were included, with the mean age of 65\u2009years old, ranging from 36 to 89\u2009years. The 5\u2010year OS rate was 43% (mean 51\u2009months, 95% confidence interval [CI]\u2009=\u200939\u201364). Significant prediction of a worse prognosis for 5\u2010year OS rate was observed under univariate analysis for advanced T stage, positive margin, identified PNI, and higher Ki\u201067 index, respectively. Advanced T stage was confirmed to be an independent prognostic factor strongly affecting 5\u2010year OS rate among this cohort of patients using a multivariate cox proportional hazard model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found that clinicopathological parameters, especially postoperative pathological parameters, play a critical role in predicting the prognosis of ETBSCC patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27818","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T04:59:26Z","timestamp":1718254766000},"page":"2870-2877","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Squamous cell carcinoma of ear and temporal bone: A retrospective study on clinicopathological predictors"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6286-200X","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pathology, Tianjin First Central Hospital The First Central Hospital Affiliated of Nankai University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bronwyn","family":"Tucker","sequence":"additional","affiliation":[{"name":"School of Medical English and Health Communication Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhan\u2010Dong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tianjin First Central Hospital The First Central Hospital Affiliated of Nankai University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tianjin First Central Hospital The First Central Hospital Affiliated of Nankai University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue\u2010Xi","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tianjin First Central Hospital The First Central Hospital Affiliated of Nankai University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Juan","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tianjin First Central Hospital The First Central Hospital Affiliated of Nankai University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Fang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tianjin First Central Hospital The First Central Hospital Affiliated of Nankai University  Tianjin 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