{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:41:06Z","timestamp":1771306866999,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypopharyngeal cancer, constituting 3%\u20135% of head and neck cancers, predominantly presents as squamous cell carcinoma, with a 5\u2010year overall survival rate of approximately 40%. Treatment modalities for locally advanced cases include chemoradiotherapy; however, the role of upfront neck dissection (UND) remains controversial. This study aimed to investigate the effect of UND on definitive radiotherapy in locally advanced hypopharyngeal carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective analysis included consecutive patients with locally advanced hypopharyngeal squamous cell carcinoma who were treated in our department between January 2007 and June 2023. All patients underwent definitive radiotherapy (dRT) at a total dose of 70\u2009Gy in 35 fractions. The patients were categorized into two groups: dRT (radiotherapy with or without chemotherapy) and UND\u2010dRT (surgical neck dissection followed by radiotherapy). Univariate Cox models and multivariate analyses were conducted to investigate the independent prognostic factors for overall survival and locoregional control rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study included 115 patients, predominantly male (109\/115), with a median age of 66\u2009years. Clinical stage and chemotherapy distribution differed significantly between the dRT and UND\u2010dRT groups. The 3\u2010year overall survival and locoregional control rates for all patients were 63.8% and was 63.3%, respectively. The UND\u2010dRT group exhibited a trend toward improved locoregional control, although this difference was not statistically significant. The multivariate analysis revealed that UND was an independent factor significantly associated with improved overall survival and locoregional control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provided evidence supporting the effectiveness of UND in conjunction with definitive radiotherapy for locally advanced hypopharyngeal carcinoma. Future research should focus on validating and refining these findings through well\u2010designed prospective multicenter trials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27839","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T10:19:30Z","timestamp":1717669170000},"page":"2815-2823","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The role of upfront neck dissection in definitive radiotherapy for locally advanced hypopharyngeal squamous cell carcinoma: A single\u2010center retrospective analysis"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4393-1828","authenticated-orcid":false,"given":"Atsuto","family":"Katano","sequence":"first","affiliation":[{"name":"Department of Radiology Headand Neck Surgery, The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideomi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Radiology Headand Neck Surgery, The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Saito","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology Headand Neck Surgery, The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenya","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology Headand Neck Surgery, The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000492299"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010017\u20104766\u20106"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.09.025"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000492305"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29186"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12031237"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0022215116000529"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/01455613211013084"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1811"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.12626"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2023.03.215"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957\u2010020\u201001866\u2010z"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2016.03.003"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2017.10.016"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.10.010"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28893"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26881"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2017.07.011"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0225962"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.577"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(20)30737\u20103"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(20)30327\u20102"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.ccr\u201023\u20102303"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998211004586"}],"container-title":["Head &amp; 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