{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:04:17Z","timestamp":1778133857041,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of timing of PORT initiation for major salivary gland cancers on survival is unknown. We aim to examine the impact of PORT timeliness on overall survival (OS) of patients with major salivary gland cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional analysis using data from the National Cancer Database (2004\u20132017) and included patients with major salivary gland cancer treated with surgery and PORT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 5701 patients were included (3133 [55%] male, 4644 [82%] white, mean age 59\u2009\u00b1\u200916\u2009years). For the overall cohort, PORT &gt;6\u2009weeks was not associated with decreased OS (1.00 aHR, 95% CI 0.89\u20131.11). When specifically examining patients with mucoepidermoid carcinoma, PORT &gt;6\u2009weeks was associated with a decreased OS (1.27 aHR, 95% CI 1.01\u20131.58).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, this analysis did not demonstrate a survival benefit for initiating PORT within 6\u2009weeks for patients with salivary gland malignancies. Subset analysis did support initiating PORT within 6\u2009weeks after resection for patients with mucoepidermoid carcinomas. This was not demonstrated in other major salivary gland cancer histologies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27845","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T09:04:05Z","timestamp":1718183045000},"page":"2861-2869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Timing of postoperative radiation therapy for major salivary gland cancers"],"prefix":"10.1002","volume":"46","author":[{"given":"Flora","family":"Yan","sequence":"first","affiliation":[{"name":"Lewis Katz School of Medicine at Temple University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8377-0905","authenticated-orcid":false,"given":"Jeffrey C.","family":"Liu","sequence":"additional","affiliation":[{"name":"Lewis Katz School of Medicine at Temple University  Philadelphia Pennsylvania USA"},{"name":"Division of Head and Neck Surgery Fox Chase Cancer Center  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Shulman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fox Chase Cancer Center  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5730-2099","authenticated-orcid":false,"given":"Thomas J.","family":"Galloway","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fox Chase Cancer Center  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Ridge","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Surgery Fox Chase Cancer Center  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M. K. L.","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119730248.ch13"},{"key":"e_1_2_9_3_1","unstructured":"National Comprehensive Cancer Network.Head and neck cancers.https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/head-and-neck.pdf. Published 2023. Accessed August 4 2023"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30939"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2022.1389"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26516"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817717661"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30902"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2022.100602"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23825"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4578-0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34932"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.09.042"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-25468-9"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000386"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.2168"},{"key":"e_1_2_9_17_1","unstructured":"ClinicalTrials.gov.Radiation therapy with or without chemotherapy in treating patients with high\u2010risk malignant salivary gland tumors that have been removed by surgery.https:\/\/www.clinicaltrials.gov\/study\/NCT01220583. Published 2023. Accessed January 2 2024"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2019.05.06"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.27845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T11:23:15Z","timestamp":1728904995000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.27845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,12]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/hed.27845"],"URL":"https:\/\/doi.org\/10.1002\/hed.27845","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,12]]},"assertion":[{"value":"2024-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}