{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:25:05Z","timestamp":1789827905892,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sinonasal undifferentiated carcinoma (SNUC) is a rare, aggressive disease with ambiguous management and poor prognosis. This study aimed to evaluate the role of radiation therapy (RT) and explore the optimal treatment sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of survival trends of 410 SNUC patients between 1973 and 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 5\u2010year cancer\u2010specific survival (CSS) rate (45.1%) and overall survival (OS) rates (38.1%) were reported in the 84\u2010month median follow\u2010up. Radiotherapy was a prognosticator for improving CSS (hazard ratio [HR]\u2009=\u20090.425, 95% confidence interval [CI]: 0.299\u20130.603, <jats:italic>p<\/jats:italic>\u2009=\u20090.000) and OS (HR\u2009=\u20090.415, 95% CI: 0.303\u20130.570, <jats:italic>p<\/jats:italic>\u2009=\u20090.000), either with surgery (<jats:italic>p<\/jats:italic>\u2009=\u20090.000) or without surgery (<jats:italic>p<\/jats:italic>\u2009=\u20090.000). However, in a combined therapy of surgery and RT, preoperative and postoperative RT (5\u2010year OS rates were 47.1% and 45.6%, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.486) were not significantly different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Radiotherapy plays a key role in improving SNUC survival rates. No significant difference in survival rates was observed in preoperative and postoperative RT treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27862","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T06:29:00Z","timestamp":1722493740000},"page":"150-158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The role of radiotherapy in the treatment of sinonasal undifferentiated carcinoma: A population\u2010based analysis"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0642-5320","authenticated-orcid":false,"given":"Xin","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Oncology The Second Hospital of Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Oncology The Second Hospital of Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Oncology The Second Hospital of Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Oncology The Second Hospital of Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200212000-00007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-009-0170-8"},{"key":"e_1_2_8_4_1","first-page":"94","article-title":"Incidence and survival patterns of sinonasal undifferentiated carcinoma in the United States","volume":"76","author":"Chambers KJ","year":"2015","journal-title":"J Neurol Surg B Skull Base"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198611000-00004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812440932"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino14.054"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.06.057"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2554-5"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e31825eb3a5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.10.008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.10.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816629649"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200208000-00023"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23463"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000189691.04140.02"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20693"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20748"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21861"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22143"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00353"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2013.10.001"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1236165"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10396"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198708000-00003"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32776"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2019.07.008"}],"container-title":["Head &amp; 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