{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T01:51:55Z","timestamp":1783389115227,"version":"3.54.6"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>SWI\/SNF complex\u2010deficient sinonasal carcinomas are rare, genetically distinct, and aggressive entities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>SMARCB1 and SMARCA4 immunohistochemistry was retrospectively performed on a cohort of undifferentiated, poorly differentiated, and poorly defined sinonasal carcinomas. Survival outcomes were compared between SMARCB1\/SMARCA4 (SWI\/SNF complex)\u2010deficient and \u2010retained groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight SWI\/SNF complex\u2010deficient (six SMARCB1\u2010deficient, two SMARCA4\u2010deficient) cases were identified among 47 patients over 12\u2009years. Triple\u2010modality treatment was more frequently utilized in SWI\/SNF complex\u2010deficient carcinomas than in SWI\/SNF complex\u2010retained carcinomas (71.4% vs. 11.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001). After a median follow\u2010up of 21.3 (IQR 9.9\u201356.0) months, SWI\/SNF complex\u2010deficient sinonasal carcinomas showed comparable recurrence rates (57.1% vs. 52.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.839), time\u2010to\u2010recurrence (7.3 [IQR 6.6\u20138.3] vs. 9.1 [IQR 3.9\u201317.4] months, <jats:italic>p<\/jats:italic>\u2009=\u20090.531), and overall survival (17.7 [IQR 11.8\u201367.0] vs. 21.6 [IQR 8.9\u201356.0] months, <jats:italic>p<\/jats:italic>\u2009=\u20090.835) compared to SWI\/SNF complex\u2010retained sinonasal carcinomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Triple\u2010modality treatment may improve survival in SWI\/SNF complex\u2010deficient sinonasal carcinomas.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27864","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T10:40:11Z","timestamp":1720176011000},"page":"14-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Outcomes of <scp>SWI<\/scp>\/<scp>SNF<\/scp> complex\u2010deficient sinonasal carcinomas in a Southeast Asian cohort"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7534-2545","authenticated-orcid":false,"given":"Xinni","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingcheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok Seng","family":"Loh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery National University Hospital  Singapore Singapore"},{"name":"Department of Otolaryngology Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Sian","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charmaine Si Min","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terese Huiying","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery Ng Teng Fong General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yew Kwang","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeng Swan","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donovan Kum Chuen","family":"Eu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-021-01406-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000258"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2016.81.031021"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-022-01416-x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000797"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001428"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2020.08.004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-019-01065-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-015-1853-1"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4841"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-016-0752-3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2013-0390"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2021-0001-OA"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2022.01.114"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.310"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00353"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14133285"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1693659"},{"issue":"3","key":"e_1_2_8_20_1","article-title":"Immunotherapy for SMARCB1\u2010deficient sarcomas: current evidence and future developments","volume":"10","author":"Ngo C","year":"2022","journal-title":"Biomedicine"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30451-4"}],"container-title":["Head &amp; 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