{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T07:29:13Z","timestamp":1772695753116,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chemoradiation therapy with high\u2010dose cisplatin is the standard regimen against advanced squamous cell carcinoma of the larynx (SCC\u2010L). However, patients with renal dysfunction are ineligible for this regimen. We investigated the effectiveness and feasibility of selective intra\u2010arterial low\u2010dose cisplatin infusion and radiotherapy (modified [m]\u2010RADPLAT) for patients with impaired renal function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the data of 77 patients with SCC\u2010L who received m\u2010RADPLAT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen and 63 patients had creatinine clearance (CrCl) values of 30\u2009\u2264\u2009CrCl\u2009&lt;\u200960\u2009mL\/min and \u226560\u2009mL\/min, respectively. The m\u2010RADPLAT regimen led to no significant changes in serum creatinine or CrCl values post\u2010treatment. The 5\u2010year local control, overall survival, and laryngectomy\u2010free survival rates of the CrCl\u2009&lt;\u200960 and \u226560 groups were 90.0% and 90.5%, 100% and 81.8%, and 100% and 79.0%, respectively. Grade 3 or higher toxicity rates were not significantly different between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The m\u2010RADPLAT regimen yielded favorable survival rates and clinical outcomes in patients with impaired renal function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27873","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T10:20:36Z","timestamp":1721730036000},"page":"3085-3094","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness and feasibility of selective intra\u2010arterial low dose of cisplatin infusion and concomitant radiotherapy for patients with advanced laryngeal cancer with impaired renal function: A retrospective cohort study"],"prefix":"10.1002","volume":"46","author":[{"given":"Yuji","family":"Imahara","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck 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