{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:08:38Z","timestamp":1747148918217,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There has been no study in which the correlation between clinical results and dosimetry based on a 3D treatment planning system in patients with <jats:sup>198<\/jats:sup>Au grains for head and neck cancer was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two patients who were treated with <jats:sup>198<\/jats:sup>Au grains for head and neck cancer were reviewed. Twenty\u2010five patients were treated with brachytherapy alone and seven patients were treated with a combination of brachytherapy and neoadjuvant external beam radiation therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With a median observation period of 60\u2009months, the 5\u2010year local control rate was 82.9%. V<jats:sub>85Gy<\/jats:sub> of CTV in patients with local recurrence tended to be lower than that in patients without local recurrence (<jats:italic>p<\/jats:italic>\u2009=\u20090.07). The maximum dose of the keratinized gingiva in patients in whom bone exposure occurred was significantly higher than that in patients in whom bone exposure did not occur (<jats:italic>p<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dose distribution with <jats:sup>198<\/jats:sup>Au grains can predict local control and late adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27874","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T09:36:23Z","timestamp":1721122583000},"page":"3022-3029","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of dose distribution by a <scp>3D<\/scp> planning system for brachytherapy with <scp><sup>198<\/sup>Au<\/scp> grains for head and neck cancer"],"prefix":"10.1002","volume":"46","author":[{"given":"Keita","family":"Kishida","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Jingu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rei","family":"Umezawa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Tohoku University Graduate School of Medicine  Sendai 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