{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T18:14:19Z","timestamp":1775844859272,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Swallowing function in patients with head and neck cancer (HNC) is often assessed pre\u2010treatment, during and at intervals post\u2010treatment to identify those with dysphagia as early as possible. This study aims to investigate the minimal clinical important difference (MCID) for the 100\u2009mL water swallow test (100\u2009mL WST) to increase its utility in clinical practice and in clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 211 HNC patients, treated by\u00a0either single or combined modality were included. Patients completed both the 100\u2009mL WST and M.D. Anderson Dysphagia Inventory (MDADI) at baseline (i.e., prior to treatment) and 12\u2009months post\u2010treatment. The MCID for the 100\u2009mL WST was calculated using two approaches of the anchor\u2010based method (using the MDADI), including mean change, and ROC curve. Additionally, the distribution\u2010based method was used utilizing the half standard deviation approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the anchor\u2010based method, a 4\u2009mL\/s in the 100\u2009mL WST was defined as an MCID for deterioration, with a sensitivity of 75% and a 1\u2010specificity of 46%. In contrast, a change of 5\u2009mL\/s was deemed as an MCID for improvement, based on the distribution\u2010based method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings showed that deterioration of 4\u2009mL, or an increase of 5\u2009mL from baseline to 12\u2009months post\u2010HNC treatment equates to an MCID from the patients' perspective. Based on these findings, it may be beneficial to increase the utilization of the 100\u2009mL WST in clinical practice to observe the changes, and in clinical trials to interpret and compare different study arms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27885","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T11:17:02Z","timestamp":1721819822000},"page":"3095-3102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The timed <scp>100 mL<\/scp> water swallow test for patients with head and neck cancer: What constitutes a clinically significant difference?"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6109-8374","authenticated-orcid":false,"given":"Jenan A.","family":"Altamimi","sequence":"first","affiliation":[{"name":"Kuwait Cancer Control Centre, Ministry of Health  Kuwait City Kuwait"},{"name":"Institute of Population Health\/Liverpool Head and Neck Centre University of Liverpool  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet A.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Roe","sequence":"additional","affiliation":[{"name":"Department of Speech, Voice and Swallowing The Royal Marsden NHS Foundation Trust  London UK"},{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Imperial College Healthcare NHS Trust  London UK"},{"name":"Department of Surgery and Cancer Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne M.","family":"Patterson","sequence":"additional","affiliation":[{"name":"Institute of Population Health\/Liverpool Head and Neck Centre University of Liverpool  Liverpool 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