{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:26:07Z","timestamp":1791386767210,"version":"4.3.3"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Delay in time to treatment initiation (TTI) is associated with worsened survival outcomes in laryngeal squamous cell carcinoma (LSCC). It is unclear whether this is due to tumor growth or an increased risk of metastatic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study at one academic center included patients with LSCC who underwent radiotherapy\/chemoradiotherapy between 2005 and 2017. We examined the association between tumor growth rate (TGR) and survival outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 105 patients (mean age, 63.8\u2009\u00b1\u200911.1\u2009years; 72% male), the threshold between \u201cslow\u2010growing\u201d and \u201cfast\u2010growing\u201d tumors was &gt;0.036\u2009mL\/day (survival) and\u2009&gt;0.082\u2009mL\/day (recurrence). Faster growth was associated with worse overall survival (OS) (hazard ratio, 1.97; 95% confidence interval [CI], 0.94\u20134.13) and increased recurrence (odds ratio, 9.10; 95% CI, 2.40\u201334.4).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TGR\u2009&gt;0.036\u2009mL\/day during TTI was associated with decreased OS, and\u2009&gt;0.082\u2009mL\/day was associated with increased recurrence. Tumor measurement in patients experiencing delay may identify those who could benefit from escalated therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27888","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T10:37:38Z","timestamp":1721817458000},"page":"23-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of tumor growth rate with overall survival and recurrence among patients with laryngeal squamous cell carcinoma"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7325-4648","authenticated-orcid":false,"given":"Faye G.","family":"Zhang","sequence":"first","affiliation":[{"name":"Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankar","family":"Viswanathan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard V.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Montefiore Medical Center and Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley A.","family":"Schiff","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Montefiore Medical Center and Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9389-2332","authenticated-orcid":false,"given":"Thomas J.","family":"Ow","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Montefiore Medical Center and Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2247-3361","authenticated-orcid":false,"given":"Madhur K.","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Montefiore Medical Center and Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafi","family":"Kabarriti","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Montefiore Medical Center and Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0907-2102","authenticated-orcid":false,"given":"Vikas","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Montefiore Medical Center and Albert Einstein College of Medicine  Bronx New York 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