{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:45:18Z","timestamp":1762389918787,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies have examined health\u2010related quality of life (HRQOL) outcomes in long\u2010term total laryngectomy survivors in relation to the type of hypopharyngeal defect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was performed in long\u2010term total laryngectomy survivors, treated between 2000 and 2020. The primary outcome was HRQOL, assessed using the FACE\u2010Q Head and Neck Cancer Module, in relation to the type of hypopharyngeal closure (primary closure, partial or circumferential reconstruction).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010nine survivors were included with a median follow\u2010up of 92.1\u2009months (IQR 75.6\u2013140.2\u2009months). Patients requiring partial hypopharyngeal reconstruction (<jats:italic>n<\/jats:italic>\u2009=\u200918) scored significantly worse than patients with primary closure (<jats:italic>n<\/jats:italic>\u2009=\u200951) on 4 of 13 FACE\u2010Q domains: functional domains of eating (<jats:italic>p<\/jats:italic>\u2009=\u20090.03), speech (<jats:italic>p<\/jats:italic>\u2009=\u20090.05), and swallowing (<jats:italic>p<\/jats:italic>\u2009=\u20090.03), and the psychological domain of speaking\u2010related distress (<jats:italic>p<\/jats:italic>\u2009=\u20090.02). No statistically significant differences were found between the circumferential hypopharyngeal defect reconstruction group (<jats:italic>n<\/jats:italic>\u2009=\u200910). Stricture occurrence was the only clinical factor associated with worse eating, speaking, swallowing, eating\u2010related distress, and cancer worry in multivariable analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Several functional and psychological domains were significantly worse following partial hypopharyngeal reconstruction than in patients who received primary closure. Efforts to reduce stricture rates to enhance reconstructive outcomes following total laryngectomy merit further research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27896","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T10:40:33Z","timestamp":1721817633000},"page":"3123-3132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Associations between hypopharyngeal defect closure and quality of life in long\u2010term total laryngectomy survivors"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9430-4878","authenticated-orcid":false,"given":"Anthony M.","family":"Tonsbeek","sequence":"first","affiliation":[{"name":"Department of Plastic &amp; Reconstructive Surgery, Erasmus MC Cancer Institute University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline A.","family":"Hundepool","sequence":"additional","affiliation":[{"name":"Department of Plastic &amp; Reconstructive Surgery, Erasmus MC Cancer Institute University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aprilia L.","family":"Molier","sequence":"additional","affiliation":[{"name":"Department of Plastic &amp; Reconstructive Surgery, Erasmus MC Cancer Institute University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eveline","family":"Corten","sequence":"additional","affiliation":[{"name":"Department of Plastic &amp; Reconstructive Surgery, Erasmus MC Cancer Institute University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Rijken","sequence":"additional","affiliation":[{"name":"Department of Plastic &amp; Reconstructive Surgery Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aniel","family":"Sewnaik","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery, Erasmus MC Cancer Institute University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6941-7734","authenticated-orcid":false,"given":"Marc A. M.","family":"Mureau","sequence":"additional","affiliation":[{"name":"Department of Plastic &amp; Reconstructive Surgery, Erasmus MC Cancer Institute University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23305"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31815a9ed3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.04.048"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.05.009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21343"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2022.106047"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106133242402"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29027"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12726"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24918"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.6.526"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24796"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820957962"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2007.09.030"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16101804"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27667"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31900"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2012.10.008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.12.006"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2024.106813"},{"key":"e_1_2_8_22_1","first-page":"321","volume-title":"Proceedings of the IV Berkeley Symposium on Mathematical Statistics and Probability","author":"Rasch G","year":"1961"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29857"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200001000-00018"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.04.005"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(98)00049-9"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24902"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25404"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.430"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00238-021-01893-3"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104586"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29215"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000191179.58054.80"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30406"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815607345"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000001776"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2023.04.009"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.27896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T10:08:25Z","timestamp":1731665305000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.27896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,24]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/hed.27896"],"URL":"https:\/\/doi.org\/10.1002\/hed.27896","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"type":"print","value":"1043-3074"},{"type":"electronic","value":"1097-0347"}],"subject":[],"published":{"date-parts":[[2024,7,24]]},"assertion":[{"value":"2024-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}