{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:43:39Z","timestamp":1793828619458,"version":"4.6.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypocalcemia is the most common postoperative complication of total thyroidectomy. Near\u2010infrared autofluorescence (NIRAF) technology is a surgical adjunct that has been increasingly utilized with the aim of preventing postoperative hypocalcemia, but its clinical benefits have not yet been firmly established. The aim of this study was to assess the clinical benefit of utilizing NIRAF technology in patients undergoing total thyroidectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis of randomized clinical trials was performed according to PRISMA guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven randomized clinical trials with 1437 patients (318 males, 22.13%) undergoing total thyroidectomy were included for analysis. Risk of postoperative hypocalcemia was reduced in the NIRAF arm (RR, 0.65; 95%CI, 0.50\u20130.84). Use of NIRAF was also associated with a reduction in the risk of permanent parathyroid dysfunction (RR, 0.46; 95%CI, 0.22\u20130.95) and inadvertent parathyroid gland resection (RR, 0.40; 95%CI, 0.26\u20130.60).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We present a systematic review and meta\u2010analysis of randomized clinical trials examining the impact of NIRAF technology on preservation of parathyroid function. Our results suggest that use of camera\u2010based NIRAF technology reduces the risk of postoperative hypocalcemia, permanent parathyroid dysfunction, and inadvertent parathyroid gland resection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.27900","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T02:41:47Z","timestamp":1722912107000},"page":"225-234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Camera\u2010based near\u2010infrared autofluorescence versus visual identification in total thyroidectomy for parathyroid function preservation: Systematic review and meta\u2010analysis of randomized clinical trials"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9957-149X","authenticated-orcid":false,"given":"Luca","family":"Canali","sequence":"first","affiliation":[{"name":"Division of Thyroid and Parathyroid Endocrine Surgery, Department of Otolaryngology \u2013 Head and Neck Surgery, Massachusetts Eye and Ear Infirmary Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Italy"},{"name":"Otorhinolaryngology Unit IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika D.","family":"Russell","sequence":"additional","affiliation":[{"name":"Division of Thyroid and Parathyroid Endocrine Surgery, Department of Otolaryngology \u2013 Head and Neck Surgery, Massachusetts Eye and Ear Infirmary Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthea","family":"Sistovaris","sequence":"additional","affiliation":[{"name":"Division of Thyroid and Parathyroid Endocrine Surgery, Department of Otolaryngology \u2013 Head and Neck Surgery, Massachusetts Eye and Ear Infirmary Harvard Medical School  Boston Massachusetts 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\u2013 Head and Neck Surgery, Massachusetts Eye and Ear Infirmary Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Triponez","sequence":"additional","affiliation":[{"name":"Thoracic and Endocrine Surgery, Department of Surgery, Faculty of Medicine of Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fares","family":"Benmiloud","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit H\u00f4pital Europ\u00e9en Marseille  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Spriano","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Italy"},{"name":"Otorhinolaryngology Unit IRCCS Humanitas Research Hospital  Rozzano 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