{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T01:52:00Z","timestamp":1783389120376,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Induction chemotherapy (IC) recently gained importance for treatment of sinonasal undifferentiated carcinoma (SNUC). We analyzed our SNUC cases and performed a meta\u2010analysis with focus on survival\u2010rates stratified by treatment. SNUC cases at our institution were retrospectively evaluated. A systematic literature review was conducted to analyze treatment and outcome of SNUC. To calculate 5\u2010year and 2\u2010year overall survival (OS), individual patient data (IPD) were analyzed using Kaplan\u2013Meier estimators and Cox proportional hazard regression to identify associations between types of therapy and survival. A random effects model for pooled estimates of 5\u2010year survival was applied to studies without IPD data. Five\u2010year OS of our SNUC cases (<jats:italic>n<\/jats:italic>\u2009=\u20099) was 44.4%. The IPD analysis (<jats:italic>n<\/jats:italic>\u2009=\u2009192) showed a significantly better 5\u2010year OS for patients who received induction chemotherapy (72.6% vs. 44.5%). The pooled 5\u2010year OS of 13 studies identified in the literature search was 43.8%. IC should be considered in every patient diagnosed with SNUC.<\/jats:p>","DOI":"10.1002\/hed.27910","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T11:10:28Z","timestamp":1724152228000},"page":"2890-2900","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Contemporary treatment and outcome of sinonasal undifferentiated carcinoma: A meta\u2010analysis"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5444-3139","authenticated-orcid":false,"given":"Manuela","family":"Burggraf","sequence":"first","affiliation":[{"name":"Bavarian Cancer Research Center (BZKF)  Augsburg Germany"},{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Augsburg University Hospital  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schiele","sequence":"additional","affiliation":[{"name":"Institute of Mathematics Augsburg University  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubens","family":"Th\u00f6lken","sequence":"additional","affiliation":[{"name":"Bavarian Cancer Research Center (BZKF)  Augsburg Germany"},{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Augsburg University Hospital  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Jos\u00e9 Farf\u00e1n","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Institute of General Pathology and Molecular Diagnostics Augsburg University Hospital  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noran","family":"Elawany","sequence":"additional","affiliation":[{"name":"Department Conservative Dentistry and Periodontology Ludwig Maximilian University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Zenk","sequence":"additional","affiliation":[{"name":"Bavarian Cancer Research Center (BZKF)  Augsburg Germany"},{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Augsburg University Hospital  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Doescher","sequence":"additional","affiliation":[{"name":"Bavarian Cancer Research Center (BZKF)  Augsburg Germany"},{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Augsburg University Hospital  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198611000-00004"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000258"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000513"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200208000-00023"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000189691.04140.02"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino14.054"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2008-5"},{"issue":"2","key":"e_1_2_11_9_1","first-page":"94","article-title":"Incidence and survival patterns of sinonasal undifferentiated carcinoma in the United States","volume":"76","author":"Chambers KJ","year":"2015","journal-title":"J Neurol Surg B Skull Base"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816629649"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00353"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26357"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22143"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22536"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-021-01406-5"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001420"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20748"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-019-0776-4"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.50.2674"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2013.10.001"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27866"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.06.057"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24834"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1668537"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21861"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28202"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-022-01046-z"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2015.020"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10396"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2016-0073"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106133242402"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.07.028"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812440932"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.10.008"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.215"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.27910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T11:24:17Z","timestamp":1728905057000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.27910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,20]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/hed.27910"],"URL":"https:\/\/doi.org\/10.1002\/hed.27910","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,20]]},"assertion":[{"value":"2023-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}