{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T08:40:05Z","timestamp":1736584805139,"version":"3.32.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study analyzed the demographics, clinicopathological, treatment, and survival characteristics of head and neck sarcomas (HNS) diagnosed in a tertiary reference center in Brazil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>HNS cases were retrospectively retrieved from the Department of Pathological Anatomy of the School of Medical Sciences of the State University of Campinas. The medical records were examined to extract demographic, clinicopathological, and follow\u2010up information. The Pearson chi\u2010square test, Kaplan\u2013Meier curve, and Cox proportional hazards regression model were employed to identify survival and potential prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 47 patients were included in the study. The majority were men (61.7%) with a mean age of 38.9\u2009years. The nasal cavity (34.0%) was the most common anatomical site. The lesions are usually presented as volume increases (78.7%). The most common histological subtypes were chondrosarcoma, osteosarcoma, and alveolar rhabdomyosarcoma. Surgical excision alone was the most common treatment modality. Local recurrence was observed in 10 cases, and metastases in 3 cases. During a mean follow\u2010up period of 71.9\u2009months, from diagnosis to the last follow\u2010up, 31 patients (65.9%) were alive without the disease. A total of 10 patients (21.3%) died of the HNS for a mean follow\u2010up period of 14.3\u2009months. The time to presentation of more than 6\u2009months (<jats:italic>p<\/jats:italic>\u2009=\u20090.0309) and the presence of metastases (<jats:italic>p<\/jats:italic>\u2009=\u20090.0315) were identified as prognostic factors for survival, while male sex was found to be an independent prognostic factor for recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, the results of this study indicate that the occurrence of a shorter lesion time to presentation and the presence of metastases were associated with a reduction in survival rates in patients with HNS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27933","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T05:33:57Z","timestamp":1727328837000},"page":"549-558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Head and neck sarcomas: Thirty years of experience in a tertiary referral center in Brazil"],"prefix":"10.1002","volume":"47","author":[{"given":"Marcelo Elias Schempf","family":"Cattan","sequence":"first","affiliation":[{"name":"Department of Pathology School of Medical Sciences, Universidade Estadual de Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8406-7947","authenticated-orcid":false,"given":"Talita de Carvalho","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medical Sciences, Universidade Estadual de Campinas (UNICAMP)  Campinas Brazil"},{"name":"Department of Oral Diagnosis Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3464-8879","authenticated-orcid":false,"given":"Luccas","family":"Lavareze","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medical Sciences, Universidade Estadual de Campinas (UNICAMP)  Campinas Brazil"},{"name":"Department of Oral Diagnosis Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9429-6743","authenticated-orcid":false,"given":"Erika Said Abu","family":"Egal","sequence":"additional","affiliation":[{"name":"Biorepository and Molecular Pathology, Huntsman Cancer Institute University of Utah (UU)  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9944-9734","authenticated-orcid":false,"given":"Albina","family":"Altemani","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medical Sciences, Universidade Estadual de Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3694-5025","authenticated-orcid":false,"given":"Fernanda Viviane","family":"Mariano","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medical Sciences, Universidade Estadual de Campinas (UNICAMP)  Campinas Brazil"},{"name":"Department of Oral Diagnosis Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2020.05.015"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19940715)74:2<697::AID\u2010CNCR2820740224>3.0.CO;2\u2010A"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyad048"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2012.08.010"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010020\u201005834\u2010x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt126"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2012.11.007"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2010.05.020"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.12.005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2014.02.003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010024\u201008477\u20104"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26426"},{"volume-title":"WHO Classification of Tumours. 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