{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T04:16:12Z","timestamp":1769400972411,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Radiotherapy is a well\u2010established treatment for lip cancer, with external radiotherapy (EBRT) or brachytherapy (BT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study evaluated outcome, tumor control, and aesthetics, for 101 patients with carcinoma of the lip, not suitable for surgery, treated with combined EBRT and BT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Squamous cell carcinoma was seen in 78 patients, basal cell carcinoma in 15, and other histologies in 8 patients. Tumors were advanced: 73% in category T2\u2010T4. Local control at 3 and 5\u2009years was 89%. Local failure appeared in 4\/56 patients (7%) with primary RT compared to 7\/45 (16%) in those with prior surgery, regional recurrence in 5 patients. Toxicity was mild. Cosmetic outcome, 87 patients evaluated, was bad for 9\/40 patients with upfront surgery compared to 1\/47 for primary RT patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.003). Seven patients died from lip cancer (7%), three with originally N+ disease (43%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combined EBRT and BT could be considered for lip tumors not candidates for surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27936","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T01:53:17Z","timestamp":1727401997000},"page":"586-598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["\u201cHigh\u2010risk\u201d tumors of the lip treated with external beam radiotherapy and high\u2010dose\u2010rate brachytherapy: Long\u2010term outcome"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2299-492X","authenticated-orcid":false,"given":"Claes","family":"Mercke","sequence":"first","affiliation":[{"name":"Department of Head, Neck, Lung and Skin Cancer, Theme Cancer Karolinska University Hospital  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