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We examined the expression of the BCL\u20102 family of molecules in NPC tumors and cell lines and explored the anticancer efficacy of BH3 mimetics in\u00a0vitro.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immunohistochemistry for BCL\u20102, MCL\u20101, BCL\u2010xL, and transcriptomic analyses was conducted on NPC tumors. The efficacy of ABT\u2010199, S63845, and ABT\u2010737 were examined as monotherapy and in combination with cisplatin in NPC cell lines. RNA sequencing was performed to identify up and downregulated pathways in sensitive cell lines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and forty\u2010nine EBV\u2010positive NPC and 15 EBV\u2010negative NPC were identified. Expression of BCL\u20102 was more frequent in EBV\u2010positive NPC. BCL\u20102, MCL\u20101, and BCL\u2010xL expression was not prognostic for overall survival. Marked sensitivity was seen with the combination of S63845 and cisplatin in NPC43.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrates the therapeutic potential of combining cisplatin and S63845, which warrants further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27973","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T13:50:35Z","timestamp":1730296235000},"page":"867-877","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Characterizing and Targeting of <scp>BCL<\/scp>\u20102 Family Members in Nasopharyngeal Carcinoma"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8966-7677","authenticated-orcid":false,"given":"A. 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