{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T05:46:32Z","timestamp":1749707192221,"version":"3.30.2"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Bisphosphonates (BPs) are widely used for osteoporosis and cancer\u2010induced bone diseases due to their antiresorptive properties, yet they pose risks such as medication\u2010related osteonecrosis of the jaw (MRONJ).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We present a unique case of concurrent oral squamous cell carcinoma (SCC) and MRONJ in a 72\u2010year\u2010old female chronically treated with oral ibandronate for osteoporosis. Following a dental extraction, she developed a nonhealing wound in the maxilla. Following conservative treatment, the patient underwent a maxillectomy and extensive tissue reconstructions to control her infection and address suspicions of an underlying malignancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histopathological examinations confirmed simultaneous osteonecrosis and well\u2010differentiated SCC in the maxillary sinus and surrounding tissues. Despite multiple surgeries, the patient's disease progressed rapidly. Upon examining the literature for patients with a history of BP use diagnosed with MRONJ and\/or SCC, a total of 16 cases report a diagnostic dilemma between MRONJ and locoregional SCC. Three of the 16 cases report a final diagnosis of concurrent MRONJ and SCC. This report is the fourth reported case of concurrency to date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The patient's complex clinical course underscores the diagnostic challenges and therapeutic dilemmas in managing concurrent MRONJ and SCC, highlighting the need for vigilant monitoring and interdisciplinary collaboration in similar cases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27974","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T07:14:22Z","timestamp":1730099662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Concurrent Oral Squamous Cell Carcinoma and Bisphosphonate\u2010Related Osteonecrosis of the Maxilla: A Case Report and Literature Review"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9617-1393","authenticated-orcid":false,"given":"Michelle","family":"Yoon","sequence":"first","affiliation":[{"name":"Thyroid, Head and Neck Cancer (THANC) Foundation  New York New York USA"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yun","sequence":"additional","affiliation":[{"name":"Thyroid, Head and Neck Cancer (THANC) Foundation  New York New York USA"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Wiedmer","sequence":"additional","affiliation":[{"name":"Department of Pathology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Brandwein\u2010Weber","sequence":"additional","affiliation":[{"name":"Department of Pathology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azita S.","family":"Khorsandi","sequence":"additional","affiliation":[{"name":"Department of Radiology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Buchbinder","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohemmed N.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"issue":"8","key":"e_1_2_6_2_1","first-page":"2893","article-title":"Zoledronic Acid Induces Significant and Long\u2010Lasting Modifications of Circulating Angiogenic Factors in Cancer Patients","volume":"9","author":"Santini D.","year":"2003","journal-title":"Clinical Cancer Research"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2005.0110"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.20160049"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-023-03034-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/2231-0762.178742"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.11.003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpdhp.2016.09.005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514560768"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bdj.2007.634"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.35607"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00224-3"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.01.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_346_19"},{"issue":"2","key":"e_1_2_6_15_1","article-title":"Co\u2010Presence of Bisphosphonate\u2010Related Osteonecrosis of the Jaw and Oral Squamous Cell Carcinoma in a Patient With Postmenopausal Osteoporosis: A Role for Chronic Traumatism?","volume":"4","author":"Giorgia Capocasale V. 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