{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:18:07Z","timestamp":1787764687409,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We investigate the association of postoperative radiotherapy (PORT) volumes and salivary function in oral cavity SCC (OSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>OSCC patients undergoing PORT 2005\u20132021 underwent modified Schirmer test (MST) pre\u2010PORT, 6 and\/or 12\u2009months post\u2010PORT. Hyposalivation rates were compared by PORT volumes. MVA identified predictors for chronic hyposalivation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 165 eligible patients, 88 (53%) received bilateral, 66 (40%) ipsilateral, and 11 (7%) no\u2010neck (primary\u2010only) PORT. Baseline characteristics were similar, except more N2b\/N2c disease received bilateral PORT vs. ipsilateral or no\u2010neck (60% vs. 36% vs. 0%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Baseline hyposalivation was similar (26% vs. 30% vs. 18%, <jats:italic>p<\/jats:italic>\u2009=\u20090.67). Hyposalivation occurred more frequently in bilateral vs. ipsilateral vs. no\u2010neck PORT at 6 (90% vs. 62% vs. 9%) and 12\u2009months (90% vs. 48% vs. 0%) (both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). On MVA, bilateral neck PORT and smoking predicted chronic hyposalivation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increasing PORT volumes predict saliva function recovery and chronic hyposalivation, informing treatment discussions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27988","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T13:52:03Z","timestamp":1730296323000},"page":"847-855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Postoperative Neck Radiotherapy Volumes on Long\u2010Term Unstimulated Saliva Flow Following Primary Surgery and Ipsilateral Neck Dissection for Oral Cavity Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"47","author":[{"given":"Claire M.","family":"Rooney","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Princess Margaret Cancer Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Bratman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Princess Margaret Cancer Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Glogauer","sequence":"additional","affiliation":[{"name":"Department of Dental Oncology Princess Margaret Cancer Centre  Toronto Canada"},{"name":"University of Toronto Faculty of Dentistry  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Princess Margaret Cancer Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3206-1903","authenticated-orcid":false,"given":"Ezra","family":"Hahn","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Hosni","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hope","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Irish","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Princess Margaret Cancer Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolie","family":"Ringash","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Spreafico","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Princess Margaret Cancer Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Waldron","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Princess Margaret Cancer Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Dental Oncology Princess Margaret Cancer Centre  Toronto Canada"},{"name":"University of Toronto Faculty of Dentistry  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"McPartlin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.10.011"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgz016"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01208"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104823"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01921"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26496"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2016.425"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2010.03.015"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2021.05.007"},{"key":"e_1_2_9_11_1","unstructured":"National Comprehensive Cancer Network \u201cClinical Practice Guidelines in Oncology: Head and Neck Cancers; 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