{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T19:36:43Z","timestamp":1774985803959,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ewing sarcoma (ES) of the ethmoid sinus with orbital involvement in an adult is very rare, with 16 reported cases in the literature. Immunohistochemical studies show small blue round cells positive for CD99 and fluorescence in\u00a0situ hybridization (FISH) testing reveals positivity for the EWSR1 gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 38\u2010year\u2010old male with a diagnosis of ES of the ethmoid sinus presented with left\u2010sided periorbital pain and edema, rhinorrhea, and proptosis. The patient underwent neoadjuvant chemotherapy, surgical resection of the left skull base, and postoperative proton radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patient tolerated chemotherapy, surgical resection, and adjuvant proton radiotherapy well with resolution of proptosis, diplopia, and pain. Due to local recurrence, he is currently undergoing adjuvant chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings provide insight on the clinical presentation and appropriate management of extraosseous ES, specifically in the ethmoid sinus in the adult population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27993","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T11:01:11Z","timestamp":1731322871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Rare Case of Ewing Sarcoma of the Left Ethmoid Sinus With Orbital Extension"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7708-9566","authenticated-orcid":false,"given":"Xiaoxuan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, and MD Program Weill Cornell Medical College  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran","family":"Abraham\u2010Aggarwal","sequence":"additional","affiliation":[{"name":"School of Industrial and Labor Relations Cornell University  Ithaca New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David I.","family":"Kutler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjac040"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/17\u2010086"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2015.548"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2013.04.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070\u2010018\u201001576\u20109"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp\u2010journals\u201010013\u20101370"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2020.12.012"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.43708"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010010\u20100227\u2010x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjy362"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013027"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2017.278"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24649"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2005.03.004"},{"key":"e_1_2_8_16_1","first-page":"735","volume-title":"Surgical Pathology of the Head and Neck","author":"Barnes L.","year":"2009"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/13577149977811"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.22038\/ijorl.2019.35555.2173"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2023.08.095"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489416681322"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_89_17"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1309\/K1XJ\u20106CXR\u2010BQQU\u2010V255"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.4833"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25830"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201027556\u20101"}],"container-title":["Head &amp; 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