{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:26:22Z","timestamp":1767338782283,"version":"3.37.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Solitary extramedullary plasmacytomas (SEP) of the head and neck are rare and pose unique challenges. This study aimed to explore the clinical spectrum and treatment outcomes of these neoplasms using multimodal management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of 13 patients with SEP of the head and neck. Data on demographics, clinical presentation, diagnostics, treatment, and survival outcomes were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One patient refused the treatment and was lost to follow\u2010up. Another one received operation alone. The other 11 patients underwent surgical resection when feasible and showed favorable responses to radiation. Two of them (16.7%) experienced local recurrence, and another two patients (16.7%) progressed to multiple myeloma (MM) within the first 2\u2009years following the initial treatment. Tumor &gt;\u20092.6\u2009cm significantly affected the post\u2010radiation prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although radiotherapy yields favorable immediate outcomes in our limited case series, a subset of cases progresses to MM within the initial 2\u2009years. Despite all tumors being categorized as Stage I, tumor size may still influence prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27998","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T12:13:43Z","timestamp":1731932023000},"page":"983-989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Outcome Analysis of Solitary Extramedullary Plasmacytoma in the Head and Neck: A Clinical Perspective"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4776-2262","authenticated-orcid":false,"given":"Po\u2010Wen","family":"Chuang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Chang Gung Memorial Hospital and Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Yu","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Pathology Chang Gung Memorial Hospital and Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ta\u2010Jen","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Chang Gung Memorial Hospital and Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Otolaryngology, Head and Neck Surgery Xiamen Chang Gung Memorial Hospital  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po\u2010Hung","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Chang Gung Memorial Hospital and Chang Gung University  Taoyuan Taiwan"},{"name":"Graduate Institute of Clinical Medical Sciences, College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of 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