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However, globally accepted guidelines for OED monitoring are lacking, despite calls for individualized management based on host and lesion characteristics. The proposed research protocol involves acquiring high\u2010quality intraoral images, assessing oral hygiene and periodontal status, eliminating chronic mechanical irritation and Candida infections, and applying adjunctive diagnostic methods like toluidine blue staining, optical evaluation, and brush cytology. Tailored follow\u2010up regimens based on individual risk assessments are emphasized, with frequent monitoring for high\u2010grade dysplasia or patients at higher risk of progression. Therefore, effective OED management should consider the patient's immune status, dietary habits, and oral microbiota, aiming to develop personalized treatment strategies that optimize patient\u2010centered care.<\/jats:p>","DOI":"10.1002\/hed.28001","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T13:10:17Z","timestamp":1731935417000},"page":"7-13","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Recommendations for Research to Develop a Patient\u2010Centered Clinical Follow\u2010Up Protocol for Oral Epithelial Dysplasia"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9423-9191","authenticated-orcid":false,"given":"Pelin","family":"G\u00fcneri","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Department of Oral and Maxillofacial Radiology Ege University  Izmir Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaye","family":"Bolukbasi","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Oral and Maxillofacial Radiology Ege University  Izmir Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betul","family":"Ilhan","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Oral and Maxillofacial Radiology Ege University  Izmir Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel B.","family":"Epstein","sequence":"additional","affiliation":[{"name":"City of Hope Comprehensive Cancer Center Duarte CA and Cedars Sinai Health System  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saman","family":"Warnakulasuriya","sequence":"additional","affiliation":[{"name":"Faculty of Dental, Oral &amp; Craniofacial Sciences King's College London, and\u00a0the WHO Collaborating Centre for Oral Cancer  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00584.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.09.017"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13056"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13501"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-04191-z"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2017.12.011"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01054.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13993"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.825266"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2023.10.002"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2007.0104"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.03.009"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-022-04486-x"},{"key":"e_1_2_6_15_1","first-page":"3077","article-title":"Is Systemic Immunosuppression a Risk Factor for Oral Cancer?","volume":"15","author":"Patini R.","year":"2023","journal-title":"A Systematic Review and Meta\u2010Analysis. 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