{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:11:47Z","timestamp":1779297107871,"version":"3.51.4"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the clinicopathological features of individuals who have cervical lymph node metastasis (CLNM) from non\u2010head and neck primary carcinomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data of 1448 patients diagnosed with CLNM from non\u2010head and neck primary carcinomas at the Yunnan Cancer Hospital, Third Affiliated Hospital of Kunming Medical University, China, from January 2013 to December 2023 were collected. The patients' general information, imaging data, and pathological information were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 780 men and 668 women among the 1448 patients, for a male\u2010to\u2010female ratio of 1.17:1. The median age was 56\u2009years (range 21\u201381\u2009years). The most prevalent primary sites in males were the lung (<jats:italic>n<\/jats:italic>\u2009=\u2009508, 65.1%) and, in females, the breast (<jats:italic>n<\/jats:italic>\u2009=\u2009276, 41.3%). The most prevalent pathological kind (<jats:italic>n<\/jats:italic>\u2009=\u2009949), or 65.5% of cases, was adenocarcinoma. There was a significant difference in the proportion of adenocarcinoma between males (<jats:italic>n<\/jats:italic>\u2009=\u2009385, 49.4%) and females (<jats:italic>n<\/jats:italic>\u2009=\u2009564, 84.4%). The common sites of CLNM from non\u2010head and neck primary carcinomas were level V (1,236 cases, 85.4%). In a subgroup of 1133 patients with primary cancer located in symmetrical or unilateral organs, 60.3% exhibited ipsilateral lymph node metastasis, 27.6% had bilateral lymph node metastasis, and 12.1% showed contralateral lymph node metastasis exclusively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For patients with CLNM, especially those with metastasis to cervical areas IV\u2010V and those with adenocarcinoma pathology, it is particularly important to screen for primary foci in the lungs, breast, urogenital system, and digestive system after excluding head and neck primary cancers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.28002","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T10:13:49Z","timestamp":1731665629000},"page":"400-409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cervical Lymph Nodes Metastasis From Non\u2010head and Neck Primary Carcinomas: A Retrospective Analysis of 1448 Patients"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1450-7626","authenticated-orcid":false,"given":"Jin\u2010Hui","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery Section II, the Yunnan Cancer Hospital Third Affiliated Hospital of Kunming Medical University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Peng","family":"Zha","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Section II, the Yunnan Cancer Hospital Third Affiliated Hospital of Kunming Medical University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Da","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Section II, the Yunnan Cancer Hospital Third Affiliated Hospital of Kunming Medical University  Kunming 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