{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T12:35:54Z","timestamp":1775565354552,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Most challenging treatment needs are in recurrent or persisting head and neck squamous cell carcinoma (HNSCC) patients after (((chemo\u2010)radiotherapy) (C)RT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This 10\u2010year retrospective study included 100 patients, who initially received (C)RT followed by neck dissection (ND). The results of computed tomography (CT) and sonography were evaluated for residual\/recurrent cervical lymph nodes and compared to the histopathology. On this basis we calculate the sensitivity, specificity, negative predictive value (NPV) and positive predictive value (PPV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 144 ND specimens were analyzed. The combination of CT and sonography (<jats:italic>n<\/jats:italic>\u2009=\u2009103) reached values 97% sensitivity, 71% specificity, 98% NPV, 66% PPV, and 81% overall accuracy.<\/jats:p><jats:p>For patients who received as primary treatment CRT the values for the combined imaging were: 100.0%, 73.5%, 100.0%, 66.7% and 82.7% respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrates that the combined use of CT and sonography reliably detects lymph node metastases, particularly in patients previously treated with CRT, even after a long time after treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.28008","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T12:59:40Z","timestamp":1732021180000},"page":"999-1005","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Contrast\u2010Enhanced Computed Tomography (<scp>CT<\/scp>) With Concordant Sonography as Sufficient Early Detection Tools for Recurrent and Persistent Cervical Metastases After (Chemo)radiotherapy (<scp>CRT<\/scp>)"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2136-0345","authenticated-orcid":false,"given":"Carl","family":"St\u00f6cker","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head &amp; Neck Surgery University Hospital Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Greve","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head &amp; Neck Surgery University Hospital Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meinrad","family":"Beer","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beate","family":"Hosch","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy University Hospital of Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F. E.","family":"Barth","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital of Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas K.","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head &amp; Neck Surgery University Hospital Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"von Witzleben","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head &amp; Neck Surgery University Hospital Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29932"},{"key":"e_1_2_7_3_1","unstructured":"National Comprehensive Cancer Network (NCCN) \u201cNational Comprehensive Cancer Network (NCCN) Guidelines: Head and Neck Cancers Version 1 \u201d2020 https: href=\"http:\/\/hed_28008.xml\">\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/head\u2010and\u2010neck.pdf."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26248"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032641"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24531"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514493"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.125.4.379"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1994.01880330022005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.193.1.8090882"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25880"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0720-048X(99)00120-5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.02.044"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.6052"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.5.435"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2014.06.023"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2545"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12998"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000214668.98592.d6"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28120"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12133"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.044792"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199611\/12)18:6<552::AID-HED10>3.0.CO;2-A"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.03.066"},{"issue":"1","key":"e_1_2_7_25_1","first-page":"151","article-title":"Metastatic Adenopathy From Nasopharyngeal Carcinoma: Successful Response to Radiation Therapy Assessed by Color Duplex Sonography","volume":"20","author":"Ahuja A. 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