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Predicting this need remains complex given mixed evidence surrounding its usage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive search was performed to identify studies examining risk factors associated with G\u2010tube placement following radiotherapy (RT) or concurrent chemoradiotherapy (CCRT)\u00a0in HNC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen retrospective studies were included (<jats:italic>n<\/jats:italic>\u2009=\u200911\u2009015). The overall prevalence of G\u2010tube placement was 44% with 76% of patients receiving reactive G\u2010tube placement. Pretreatment dysphagia, pretreatment BMI\u2009&lt;\u200918.5, and tumors in the hypopharynx were significant predictive factors for prophylactic G\u2010tube placement. Type of chemotherapy regimen, tumors in the nasopharynx, and cytokine changes were significant predictive factors for reactive G\u2010tube placement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Several factors were identified that contribute to increased risk of G\u2010tube placement and may guide current decision\u2010making algorithms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.28010","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T07:09:19Z","timestamp":1732604959000},"page":"1006-1017","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Predictors of Gastrostomy Tube Placement in Head and Neck Cancer Patients Undergoing Radiation or Chemoradiotherapy: A Systematic Review"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9699-3108","authenticated-orcid":false,"given":"Jenny 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