{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:57:34Z","timestamp":1780487854145,"version":"3.54.1"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is limited understanding of head and neck second primary tumors (SPTs) in HPV\u2010associated squamous cell carcinoma (SCC). Analogous to the concept of field cancerization of the upper airway known to contribute to the development of smoking\u2010related head and neck SPTs, this case series reports four cases of HPV\u2010associated SPTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the charts of four patients diagnosed with HPV\u2010associated oropharyngeal SCC who subsequently developed HPV\u2010associated SPTs. Clinical data was collected, including demographics, tumor characteristics, time elapsed between the two diagnoses, and treatment type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average age of the patients was 68\u2009years. All of the patients were non\u2010smokers, and none reported heavy alcohol use. All patients had the first cancer in the oropharynx. The time between the first and second diagnoses ranged from 3 and 12\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HPV has not been previously identified as a risk factor for head and neck SPTs. Given the long period between the first and second cancers and the lack of other risk factors for head and neck cancer, our case series demonstrates HPV\u2010associated head and neck SPTs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.28018","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T10:40:27Z","timestamp":1732704027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>HPV<\/scp>\u2010Associated Head and Neck Second Primary Tumors\u2014A Case Series"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6671-3949","authenticated-orcid":false,"given":"Shimrit","family":"Sharav","sequence":"first","affiliation":[{"name":"Head and Neck Specialists Sarah Cannon Cancer Institute, HCA Healthcare  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Horton","sequence":"additional","affiliation":[{"name":"Department of Head &amp; Neck Oncology Norton Cancer Institute, Norton Health  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Theodossiou","sequence":"additional","affiliation":[{"name":"Head and Neck Specialists Sarah Cannon Cancer Institute, HCA Healthcare  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Pathology, Trident Medical Center HCA Healthcare  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Neskey","sequence":"additional","affiliation":[{"name":"Head and Neck Specialists Sarah Cannon Cancer Institute, HCA Healthcare  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Day","sequence":"additional","affiliation":[{"name":"Head and Neck Specialists Sarah Cannon Cancer Institute, HCA Healthcare  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41199\u2010020\u201000057\u20103"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414\u2010431x20132703"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12123"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.55971"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514527969"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S379173"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097\u20100142(19970201)79:3<595::aid\u2010cncr24>3.0.co;2\u2010y"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.09.009"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2019.101649"},{"key":"e_1_2_6_11_1","first-page":"E1130","article-title":"Risk of Second Primary Malignancy After Nasopharyngeal Carcinoma in the United States: A Population\u2010Based Study","author":"Chan J. Y.","year":"2016","journal-title":"Head Neck"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.28018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T12:28:54Z","timestamp":1739363334000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.28018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/hed.28018"],"URL":"https:\/\/doi.org\/10.1002\/hed.28018","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,27]]},"assertion":[{"value":"2024-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}