{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:55:09Z","timestamp":1791809709899,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010731","name":"Faculty of Medicine, Chiang Mai University","doi-asserted-by":"publisher","award":["25\u20102565"],"award-info":[{"award-number":["25\u20102565"]}],"id":[{"id":"10.13039\/501100010731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study evaluated the efficacy of fluconazole prophylaxis in reducing radiation\u2010induced oral mucositis (RIOM) and <jats:italic>Candida<\/jats:italic> carriage in head and neck cancer (HNC) patients undergoing concurrent chemoradiotherapy (CCRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, double\u2010blinded, randomized controlled trial was conducted with 78 HNC patients receiving either fluconazole (100\u2009mg daily) or placebo during CCRT. The primary outcome was the incidence of grade 2 or higher RIOM. Secondary outcomes included positive <jats:italic>Candida<\/jats:italic> cultures and colony\u2010forming units (CFUs). Mixed\u2010effects ordinal logistic regression and logistic regression were used for analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fluconazole significantly reduced the incidence of grade 2 or higher RIOM at week 7 (<jats:italic>p<\/jats:italic>\u2009=\u20090.039), positive <jats:italic>Candida<\/jats:italic> carriage at week 4 (<jats:italic>p<\/jats:italic>\u2009=\u20090.024) and week 7 (<jats:italic>p<\/jats:italic>\u2009=\u20090.029), and median CFUs at week 7 (<jats:italic>p<\/jats:italic>\u2009=\u20090.050).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fluconazole significantly reduces RIOM severity and <jats:italic>Candida<\/jats:italic> colonization in HNC patients undergoing CCRT, suggesting its efficacy as a prophylactic treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.28020","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T08:21:11Z","timestamp":1733732471000},"page":"1168-1175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Fluconazole for Preventing Radiation\u2010Induced Oral Mucositis: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"47","author":[{"given":"Waranyu","family":"Ueangphairot","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3366-6146","authenticated-orcid":false,"given":"Pooriwat","family":"Muangwong","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phimchat","family":"Suwannaphong","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirida","family":"Youngchim","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patcharin","family":"Thammasit","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kittikun","family":"Kittidachanan","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imjai","family":"Chitapanarux","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00089"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-04885-z"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.02.003"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-011-1154-4"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14194746"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2354.2007.00855.x"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2012.05.008"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-005-0835-2"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyg017"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33100"},{"key":"e_1_2_13_12_1","volume-title":"A Practical Guide for Conformal and Intensity\u2010Modulated Radiation Therapy","author":"Lee N. 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Common Terminology Criteria for Adverse Events (CTCAE) \u201cCommon Terminology Criteria for Adverse Events (CTCAE) v5.0.\u201d2017 https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/docs\/ctcae_v5_quick_reference_5x7.pdf."},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.01.060"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00837"}],"updated-by":[{"DOI":"10.1002\/hed.70457","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000}}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.28020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T09:29:15Z","timestamp":1754040555000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.28020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,9]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/hed.28020"],"URL":"https:\/\/doi.org\/10.1002\/hed.28020","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,9]]},"assertion":[{"value":"2024-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}