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Thus, the main aim of this study was to provide a histological and microanatomical analysis of surgical specimens after compartmental surgery for OTSCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The present prospective observational study included primary cT3 OTSCC (according to the eighth edition of the TNM classification) treated in an academic tertiary referral center with curative compartmental surgery, from July 2016 to July 2019. Analysis of histologic macrosections allowed assessment of standard pathologic parameters as well as a detailed analysis of the position of OTSCC cells from microanatomic and topographic standpoints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 28 patients included, 71.4% were males, with a mean age of 64.9\u2009years. Nine (32.1%) patients presented satellitosis, which was always located within the T\u2010N tract. OTSCCs displaying satellitosis had a significantly higher median pathologic depth of invasion (DOI). A radiologic and pathological DOI &gt;\u200915\u2009mm significantly predicted the presence of satellites. There was a significant relationship between the presence of satellites and both positive lymph nodes and distant metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Approximately one\u2010third of cases of intermediate\u2010to\u2010advanced OTSCC are characterized by tumor satellites located in the T\u2010N tract. DOI exceeding 15\u2009mm and the presence of clinically appreciable nodal metastases best predict the presence of satellitosis. Satellite\u2010bearing OTSCC behave more aggressively, with an increased risk of distant metastasis and reduced survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.28025","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T05:09:00Z","timestamp":1734412140000},"page":"1223-1238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic Effect of Patterns of Local Extension and Satellitosis in <scp>cT3<\/scp> Squamous Cell Carcinoma of the Oral Tongue: A Prospective Observational Study"],"prefix":"10.1002","volume":"47","author":[{"given":"Nausica","family":"Montalto","sequence":"first","affiliation":[{"name":"Unit of Otorhinolaryngology\u2014Head and Neck Surgery Azienda Ospedale Universit\u00e0 di Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simonetta","family":"Battocchio","sequence":"additional","affiliation":[{"name":"Unit of 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